慢性丙型病毒性肝炎伴发焦虑抑郁症患者血清载脂蛋白B的表达水平及意义研究

Expression and Value of Serum Apolipoprotein B in Patients With Chronic Hepatitis C Accompanied by Anxiety and Depressive Disorder

目的探讨慢性丙型病毒性肝炎(CHC)伴发焦虑抑郁症患者血清载脂蛋白B(Apo B)表达水平及意义。方法选取2010年1月—2014年6月于四川省达州市中心医院住院的CHC患者100例为CHC组,另选取同时期本院体检健康者100例为对照组。采用医院焦虑和抑郁量表评估焦虑/抑郁症程度,采用Olympus 3200型全自动生化分析仪检测血清Apo B水平。比较对照组及不同焦虑或抑郁症程度CHC患者血清Apo B水平的差异。结果 100例CHC患者中无焦虑组54例、轻度焦虑组20例、中重度焦虑组26例,无抑郁症组74例、轻度抑郁症组9例、中重度抑郁症组17例。无焦虑组、轻度焦虑组、中重度焦虑组患者血清Apo B水平较对照组下降(P<0.05);无焦虑组、轻度焦虑组、中重度焦虑组患者血清Apo B水平比较,差异无统计学意义(P>0.05)。无抑郁症组、轻度抑郁症组、中重度抑郁症组患者血清Apo B水平较对照组下降(P<0.05);轻度抑郁症组、中重度抑郁症组患者血清Apo B水平较无抑郁症组下降(P<0.05);中重度抑郁症组患者血清Apo B水平较轻度抑郁症组下降(P<0.05)。结论 CHC患者伴发焦虑抑郁症与血清Apo B水平降低相关,血清Apo B水平下降与抑郁症程度相关,而与焦虑程度无明显相关关系。

Objective To investigate the apolipoprotein B（ Apo B） level and its significance of patients with chronic hepatitis C（ CHC） accompanied by anxiety or depressive disorder. Methods A total of 100 CHC patients who were hospitalized in Dazhou Central Hospital of Sichuang Province from January 2010 to June 2014 were enrolled in CHC group and 100 healthy people determined by physical examination in the same hospital and the same period were enrolled as control group. The degrees of anxiety and depressive disorder were assessed by hospital anxiety and depression scale,and Apo B level was detected by fully automatic biochemical analyzer of Olympus 3200 type. Apo B level was compared among control group and CHC subgroups with different degrees of anxiety or depressive disorder. Results Among the 100 CHC patients,non anxiety group had 54 patients,mild anxiety group had 20 patients and moderately severe anxiety group had 26 patients; non depressive disorder group had 74 patients,mild depressive disorder group had 9 patients and moderately severe depressive disorder group had 17 patients. The serum Apo B levels of non anxiety group,mild anxiety group and moderately severe anxiety group were lower than those of control group（ P〈0. 05）; the differences in serum Apo B levels among non anxiety group,mild anxiety group and moderately severe anxiety group were not significant（ P〉0. 05）. The serum Apo B levels of non depressive disorder group, mild depressive disorder group and moderately severe depressive disorder group were lower than those of control group（ P〈0. 05）; the serum Apo B levels of mild depressive disorder group and moderately severe depressive disorder group were lower than those of non depressive disorder group（ P〈0. 05）; the serum Apo B level of moderately severe depressive disorder group was lower than that of mild depressive disorder group（ P〈0. 05）. Conclusion Anxiety and depressive disorder in CHC patients is related to the decrease of serum Apo B level and the decrease of serum Apo B level is related to the degree of depressive disorder but is not related to the degree of anxiety.