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幽门螺杆菌感染与2型糖尿病患病关系的横断面研究 被引量:6

Association between Helicobacter pylori infection and prevalence of type 2 diabetes
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摘要 选取4129例健康体检人员进行横断面研究,其中男性2649例、女性1480例,平均年龄(49.1±11.3)岁,对其体检数据进行幽门螺杆菌(Hp)感染与糖尿病关系的单因素分析及非条件logistic回归分析。糖尿病组Hp感染率45.6%(706/1549),显著高于非糖尿病组的39.0%(1007/2580)(P〈0.05);新诊断糖尿病组Hp感染率最高为47.9%(470/981),高于既往诊断糖尿病组41.5%(236/568),高于非糖尿病组;Hp感染组糖化血红蛋白水平(5.88±0.64)%,高于非感染组的(5.62±0.88)%,空腹血糖和餐后2h血糖水平均高于非感染组,差异有统计学意义(均P〈0.05);非条件logistic同归结果显示,固定吸烟、腹围、收缩压、TG、LDL—C等危险因素后,Hp感染者患糖尿病的危险是非感染者的2.002倍(P〈0.05)。提示Hp感染与糖尿病的发生关系密切,是糖尿病发生的一个危险因素;有效清除Hp感染,减轻胰岛素抵抗,可减少和减缓糖尿病及其并发症的发生发展。 To investigate the association between Helicobaeter pylori (kip) infection and type 2 diabetes. Total 4 129 health check up subjects aged (49. 1 ±11.3) years ( 18 -92 years), including 2 649 males and 1 480 females were enrolled in this cross-section study. Hp infection was confirmed by 13C-urea breath test ; type 2 diabetes mellitus was diagnosed according to WHO criteria ( 1999 ). Single factor analysis and muhiple regression analysis were used to evaluate the association between Hp affection and the prevalence of type 2 diabetes. Hp infection rate in diabetic group was significantly higher than that in non-diabetic group (45.6% vs. 39. 0% , P 〈0.05). Hp infection rate in subjects with newly diagnosed diabetes was highest than those with previously diagnosed diabetes and non-diabetic subjects (P 〈 0. 05). The glycosylated hemoglobin level in Hp infection group was higher than that in non infection group [ ( 5.88± 0. 64 ) % vs. ( 5.62 ± 0. 88 ) %, P 〈 0. 05 ] ; the fasting plasma glucose and postprandial blood glucose levels in Hp infection group were also higher than those in non-infection group ( P 〈 0. 05 ). Logistic regression analysis showed that Hp intection was one of the independent risk factors of type 2 diabetes ( OR = 2. 002, 95% CI: 1. 564 - 2. 563, P 〈 0. 05 ). The study indicates that Hp intfetion is closely associated with type 2 diabetes mellitus.
出处 《中华全科医师杂志》 2016年第3期202-204,共3页 Chinese Journal of General Practitioners
关键词 螺杆菌 幽门 糖尿病 2型 横断面研究 Helicobacter pylori Diabetes mcllitus,type 2 Cross-sectional studies
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