幽门螺杆菌感染与2型糖尿病患病关系的横断面研究

Association between Helicobacter pylori infection and prevalence of type 2 diabetes

选取4129例健康体检人员进行横断面研究，其中男性2649例、女性1480例，平均年龄（49．1±11．3）岁，对其体检数据进行幽门螺杆菌（Hp）感染与糖尿病关系的单因素分析及非条件logistic回归分析。糖尿病组Hp感染率45．6％（706／1549），显著高于非糖尿病组的39．0％（1007／2580）（P〈0．05）；新诊断糖尿病组Hp感染率最高为47．9％（470／981），高于既往诊断糖尿病组41．5％（236／568），高于非糖尿病组；Hp感染组糖化血红蛋白水平（5．88±0．64）％，高于非感染组的（5．62±0．88）％，空腹血糖和餐后2h血糖水平均高于非感染组，差异有统计学意义（均P〈0．05）；非条件logistic同归结果显示，固定吸烟、腹围、收缩压、TG、LDL—C等危险因素后，Hp感染者患糖尿病的危险是非感染者的2．002倍（P〈0．05）。提示Hp感染与糖尿病的发生关系密切，是糖尿病发生的一个危险因素；有效清除Hp感染，减轻胰岛素抵抗，可减少和减缓糖尿病及其并发症的发生发展。

To investigate the association between Helicobaeter pylori （kip） infection and type 2 diabetes. Total 4 129 health check up subjects aged （49. 1 ±11.3） years （ 18 -92 years）, including 2 649 males and 1 480 females were enrolled in this cross-section study. Hp infection was confirmed by 13C-urea breath test ; type 2 diabetes mellitus was diagnosed according to WHO criteria （ 1999 ）. Single factor analysis and muhiple regression analysis were used to evaluate the association between Hp affection and the prevalence of type 2 diabetes. Hp infection rate in diabetic group was significantly higher than that in non-diabetic group （45.6% vs. 39. 0% , P 〈0.05）. Hp infection rate in subjects with newly diagnosed diabetes was highest than those with previously diagnosed diabetes and non-diabetic subjects （P 〈 0. 05）. The glycosylated hemoglobin level in Hp infection group was higher than that in non infection group [ （ 5.88± 0. 64 ） % vs. （ 5.62 ± 0. 88 ） %, P 〈 0. 05 ] ; the fasting plasma glucose and postprandial blood glucose levels in Hp infection group were also higher than those in non-infection group （ P 〈 0. 05 ）. Logistic regression analysis showed that Hp intection was one of the independent risk factors of type 2 diabetes （ OR = 2. 002, 95% CI： 1. 564 - 2. 563, P 〈 0. 05 ）. The study indicates that Hp intfetion is closely associated with type 2 diabetes mellitus.