KDR、MC2R和PCNA在产醛固酮腺瘤与肾上腺皮质增生病变中的表达和意义

The expressions and significance of kinase domain receptor,melanocortin-2 receptor and proliferating cell nuclear antigen in aldosterone-producing adenoma and adrenal cortical hyperplasia

目的：探讨激酶插入区受体（KDR）、促肾上腺皮质激素受体2（MC2R）和增殖细胞核抗原（PCNA）在产醛固酮腺瘤（APA）与肾上腺皮质增生（IHA）中的表达和意义。方法：应用免疫组织化学技术检测KDR、MC2R和PCNA在APA和IHA病变组织中（各40例）的表达情况。结果：APA组织中KDR、MC2R和PCNA的阳性表达率分别为40.0%、32.5%和85.0%;IHA组织中KDR、MC2R和PCNA的阳性表达率分别为65.0%、62.5%和77.5%;2种病变组织中,KDR、MC2R和PCNA的表达强度差异均有统计学意义（P〈0.05-P〈0.01）。结论：KDR、MC2R和PCNA在IHA病变的发生、发展中起重要作用,对于鉴别APA和IHA病变具有重要的参考意义。

Objective： To explore the expressions and significance of kinase domain receptor（ KDR）,melanocortin-2 receptor（ MC2R）and proliferating cell nuclear antigen（ PCNA） in aldosterone-producing adenoma（ APA） and adrenal cortical hyperplasia（ IHA）.Methods： The expressions of KDR,MC2 R and PCNA in 40 cases APA and 40 cases IHA lesions were detected by immunohistochemistry. Results： The positive expression rates of KDR,MC2 R and PCNA in APA lesions were 40. 0%,32. 5% and85. 0%,respectively. The expression rates of KDR,MC2 R and PCNA in IHA lesions were 65. 0%,62. 5% and 77. 5%,respectively.The differences of KDR,MC2 R and PCNA expressions between APA and IHA were statistically significant（ P〈0. 05 to P〈0. 01）.Conclusions： The KDR,MC2 R and PCNA play an important role in the occurrence and development of IHA,which have important reference meaning in the differentiation of APA and IHA lesions.