手足口病患儿免疫球蛋白IgG亚类和补体C3、C4及C反应蛋白水平分析

Levels of serum immunoglobulin Ig G subclass,complement C3 and C4,and C reactive protein in children with hand-foot-mouth disease

目的:探讨手足口病患儿免疫球蛋白IgG亚类和补体C3、C4及C反应蛋白(CRP)水平的变化及临床意义。方法:选取重型手足口病患儿103例作为重型组,普通手足口病患儿301例作为普通组,另选取同期健康体检的正常儿童50名作为对照组,检测3组免疫球蛋白IgG亚类和补体C3、C4及CRP水平。结果:重型组IgG1、IgG3和补体C3、C4水平明显低于对照组和普通组(P<0.01),CRP水平均明显高于对照组和普通组(P<0.01),普通组IgG1、IgG2、IgG3、IgG4和补体C3、C4及CRP水平与对照组差异均无统计学意义(P>0.05)。结论:重型手足口病患儿体液免疫应答存在异常,患儿可在病毒感染的基础上继发细菌感染,联合检测免疫球蛋白IgG亚类和补体C3、C4及CRP水平对手足口病患儿病情进展具有一定的临床指导意义。

Objective： To explore the levels of serum immunoglobulin Ig G subclass,complement C3 and C4,and C reactive protein（ CRP） in children with hand-foot-mouth disease（ HFMD） and its clinical significance. Methods： One hundred and three severe HFMD children and 301 common HFMD children were divided into the severe and common groups,50 healthy children were set as the control group. The serum levels of immunoglobulin Ig G subclass,complement C3 and C4,and CRP in 3 groups were detected. Results： The levels of immunoglobulin Ig G1 and Ig G3,complement C3 and C4 in severe group were significantly lower than those in control group and common group（ P〈0. 01）,the level of CRP in severe group were significantly higher than that in the control group and common group（ P〈0. 01）. The differences of the levels of immunoglobulin Ig G1,Ig G2,Ig G3 and Ig G4,complement C3 and C4,and CRP between the common group and control group were not statistically significant（ P〈0. 05）. Conclusions： The humoral immune response in severe HFMD children is abnormal,children can be secondarily bacteria infected on the basis of virus infection. The combined detections of immunoglobulin Ig G subclass,complement C3 and C4,and CRP has certain clinical significance in understanding the progress of the HFMD.