肝硬化患者血清瘦素水平变化及临床意义

Clinical significance of the serum leptin in patients with liver cirrhosis

目的通过测定肝硬化患者血清瘦素水平,探讨肝硬化与瘦素的相关性,不同肝功能下、不同病因下血清瘦素水平与相关因素。方法选择肝硬化患者86例,对照组45例,分别测定肝功能、身高、体重等相关指标,并将肝硬化组患者进行Child-Pugh分级以及按照病因学分类。血清瘦素水平采用酶联免疫吸附试验(ELISA)法测定。结果肝硬化组患者血清瘦素水平明显高于对照组(P<0.05);按Child-Pugh分级,随着肝功能的下降,血清瘦素水平逐渐升高;按病因学分类,乙型肝炎后肝硬化、原发性胆汁性肝硬化及酒精性肝硬化患者血清瘦素水平均高于健康对照组(P<0.05)。结论肝硬化患者血清瘦素明显升高,与肝功能及肝硬化病因学等密切相关。

Objective By measuring serum leptin levels in patients with liver cirrhosis, and investigate the relationship with liver function, etiology and related factors. Methods 86 patients with liver cirrhosis and 40 controlled healthy persons were selected. Other testing measurements such as liver function, the height, body weight of candidates were measured respectively. The liver cirrhosis patients were divided into different groups according to Child-Pugh system and etiology. Serum leptin levels were determined by enzyme-linked immunosorbent assay（ELISA）. Results The serum leptin levels in liver cirrhosis group were significantly higher than those in the control group （P 〈 0. 05 ） , and the serum leptin levels were increased with the severity of abnormal liver function. Classification according to etiology, the serum leptin levers of hepatitis B cirrhosis patients, primary biliary cirrhosis patients and alcoholic cirrhosis patients were higher than the control group （P 〈 0. 05 ）. Conclusion The serum leptin levels in liver cirrhosis group were significantly higher than those in the control group, and those were closely related to liver function and etiology.