血清同型半胱氨酸与冠状动脉病变的相关性研究

Research of correlation between serum homocysteine and coronary artery disease

目的研究血清同型半胱氨酸(Hcy)与冠状动脉病变之间存在的相关性。方法 70例已行冠状动脉造影患者,根据患者的疾病类型进行分组,其中稳定型心绞痛患者27例(SA组),急性冠状动脉综合征患者43例(ACS组);同期40例健康体检者作为对照组,采用循环酶法测定所有研究对象的血清Hcy水平,研究其与冠状动脉病变程度之间存在的相关性。结果三组血清Hcy水平比较,ACS组明显较SA组和对照组高,SA组较对照组高,差异均具有统计学意义(P<0.05);ACS组血清Hcy水平与冠状动脉病变的Gensini积分呈正相关(r=0.472,P<0.05)。结论冠心病患者,其血清Hcy水平明显上升,提示两者之间具有密切相关性,可采用血清Hcy水平测定作为冠状动脉病变情况的预测指标。

Objective To research correlation between serum homocysteine（Hcy） and coronary artery disease. Methods A total of 70 patients receiving coronary arteriography were divided by their disease types into 27 cases with stable angina pectoris（SA group） and 43 cases with acute coronary syndrome（ACS group）. There were 40 healthy people at the same time period as control group. Enzymatic cycling assay was applied to detect serum Hcy levels in all study subjects for research of correlation between serum Hcy and coronary artery disease degree. Results ACS group had obviously higher serum Hcy level than SA group and control group, and SA group also had higher serum Hcy level than control group. Their differences all had statistical significance（P〈0.05）. ACS group had positive correlation between serum Hcy and Gensini score of coronary artery disease（r=0.472, P〈0.05）. Conclusion Remarkable increase of serum Hcy level in coronary heart disease patients shows a close correlation between them. Implement of serum Hcy level detection can act as predictive index for coronary artery disease condition.