祛瘀汤治疗晚期非小细胞肺癌高凝状态气虚血瘀证的临床研究

The clinical research of the Quyu prescriptions in treatment of advanced non-small cell lung cancer with high coagulation state Qi-deficiency blood stasis

目的:探讨祛瘀汤对非小细胞肺癌(NSCLC)高凝状态气虚血瘀证的改善作用。方法:NSCLC合并血液高凝状态患者80例,按照随机数字表法分为观察组和对照组各40例,两组均给予常规抗肿瘤及对症处理,观察组给予祛瘀汤口服,以两周为1个疗程。观察治疗前后血小板、血凝指标、中医症候积分及KPS评分变化。结果:治疗后对照组的血浆FBI、DD、FDP水平较治疗前升高,而观察组较治疗前明显降低。对照组治疗后中医症候积分与治疗前比较差异无统计学意义。观察组治疗后中医症候总积分较治疗前明显改善,主要体现在体倦乏力和舌暗瘀斑方面。观察组中医症候疗效总有效率为92.5%。两组治疗前后KPS评分比较差异无统计学意义。结论:祛瘀汤在改善NSCLC患者的血液高凝状态方面效果明显,并可明显缓解中医症候。

Objective：To investigate the improvement effect of the Quyu prescriptions in treatment of advanced non-small cell lung cancer（NSCLC）with high coagulation state Qi-deficiency blood stasis.Methods：Selected 80 cases of advanced NSCLC patients divided into observation group and control group（n=40）,according to random number table method.The two groups were given conventional anti-tumor and symptomatic treatment,the observation group was given Quyu prescriptions,with 2weeks for a period of treatment.Observed the blood platelet indexes,coagulation indexes and TCM symptom integral and KPS score before and after treatment.Results：The FBI,plasma DD,FDP level of the control group after treatment was higher than that of the before treatment,the observation group was significantly lower than that of the before treatment,the difference had statistical significance.The TCM symptom integral of the control group after treatment had no statistically significant difference compared with the before treatment.The total TCM symptom integral of the observation group after treatment was obviously improved,mainly reflected in the body tired weakness and tongue dark and ecchymosis,had statistically significant difference.The the total effective rate of the observation group was 92.5%.The KPS score of the two groups before and after treatment has no statistically significant difference.Conclusion：The Quyu prescriptions can obviously improving the high blood coagulation state of the patients with NSCLC,and can obviously relieve symptoms of TCM,worthy of clinical popularization and application.