CK19与胃肠胰神经内分泌肿瘤远处转移的相关性

Correlation between CK19 and of gastroenteropancreatic neuroendocrine neoplasms with distant metastasis

[目的]探讨CK19与胃肠胰神经内分泌肿瘤(GEP NEN)远处转移的相关性。[方法]对确诊的GEP NEN患者225例相关石蜡切片的核分裂计数、Ki-67(MIB-1)、CgA、Syn、CD56和CK19等指标的免疫组化再次染色评估;按照不同部位,进行CK19与病理参数(分级、淋巴结转移、远处转移)的相关性分析及单因素生存分析。[结果]与CK19阴性相比,胰腺部位CK19阳性表达患者提示较高的远处转移率(P=0.0241),及较高的分期(P=0.036),其他部位未提示病理参数相关。单因素生存分析显示:胰腺、直肠、胃部位CK19阳性表达患者与阴性表达患者未提示预后差异性(P值分别为0.609 7、0.831 3、0.838 5)。[结论]CK19阳性仅在胰腺神经内分泌肿瘤提示较高的远处转移率和ENETS分期,CK19阳性与GEP NEN患者预后未提示相关性。

[Objective]To investigate the correlation between CK19 and gastroenteropancreatic neuroen- docrine neoplasms（GEP NEN）with distant metastasis. [Methods]A retrospective study was carried out on 225 patients with GEP NEN who were diagnosed in our hospital between the year 2009：2015. IHC marker： Ki-67（MIB-1） ,CgA,CD56,Syn,CK19 were reviewed. According to different sites,the correlation between CK19 and pathological parameters（grading,lymph node metastasis,distant metastasis）,and the correlation between CK19 and univariate survival analysis were studied. [Results]Patients with CK19 positive expres- sion in pancreas indicated higher distant metastasis rate（P= 0. 0241）and higher stage（P= 0. 036）compared with those CK19 negative. Univariate survival analysis showed that the CK19 positive expression in pancreas, rectum and stomach were not associated with poorer prognosis（P= 0. 6097,0. 8313,0. 8385）. [Conclusion]CK19 positive indicates a higher rate of distant metastasis and a higher ENETS stage only in pancreatic neuroendocrine tumors,and CK19 positive is not associated with the prognosis of GEP NEN patients.