氟哌噻吨美利曲辛片联合常规治疗对功能性消化不良效果观察

A clinical comparative study of flupentixol and melitracen tablets in treatment of refractory functional dyspepsia

[目的]观察氟哌噻吨美利曲辛片(黛力新)对功能性消化不良(FD)的疗效和安全性。[方法]将经常规治疗效果欠佳的FD患者112例随机分为A、B、C三组,A组服用氟哌噻吨美利曲辛片,B组给予常规治疗(PPI或H2受体拮抗剂,胃肠动力药),C组给予氟哌噻吨美利曲辛片联合常规治疗;各组总疗程均为8周。检测各组治疗前后焦虑自评量表(SAS)和抑郁自评量表(SDS)、FD症状评分(FDSR)、胃容纳试验。评定各组治疗效果及不良反应。[结果]治疗2、4、8周末A组、C组SAS、SDS评分均逐渐下降,临床症状评分逐渐下降;A组、C组治疗8周末胃容纳明显改善;与治疗前比较,均差异有统计学意义(P<0.01)。A组、C组治疗2、4、8周末FDSR减分率、SAS和SDS评分减分率和胃容纳改变,与B组比较均差异有统计学意义(P<0.01)。3组均无明显不良反应。[结论]氟哌噻吨美利曲辛片联合常规药物治疗FD明显优于单一内科常规药物,且起效快,安全性好。

[Objective]To evaluate the effects of various treatment on patients with refractory functional dyspepsia（FD）. [Methods]Totals of 112 patients with FD,which was refractory to conventional treatment of functional dyspepsia（FD）, were randomly divided into 3 groups： A-group（n = 39）, which received flu- pentixol and melitracen tablets（Deanxit）, B-group（n =32）, which was given conventional therapy（PPI or H2 receptor antagonists and the prokinetic medicine） ,C-group（n=41） ,which was given Deanxit combined -with conventional treatment. The total course was 8 weeks. FD symptom score（FDSR）in patients of 3 groups before and after treatment were evaluated by Self-Rating Anxiety Scale（SAS）and Self-Rating De pression Scale（SDS）. Gastric accommodation was also measured. [Results] After treatment, the scores of SAS and SDS and the clinical symptom score dramatically decreased,and gastric accommodation improved gradually in treatment groups（group A and C）when comparing with those before the treatment. It showed significant difference（P〈0.01）. No significant side effect was noted. [Conclusion]To treat of FD, combined Deanxit with conventional medicine is safe and effective.