维生素D佐治病毒性肺炎的临床研究

Clinical study on the efficacy of vitamin D in the treatment of children with viral pneumonia

目的探讨维生素D佐治病毒性肺炎的临床疗效。方法将118例病毒性肺炎患儿随机分为治疗组和对照组各59例,对照组患儿入院后均给予利巴韦林(10 mg/kg.d bid)抗病毒治疗及积极对症支持治疗,治疗组在对照组基础上于入院当晚即开始服用维生素D滴剂,两组患者均以1周为1个疗程。结果治疗前两组患儿的25-(OH)D3与Ig A水平组间比较差异均无统计学意义(P>0.05),治疗后均表现有不同程度升高,但治疗组升高程度显著大于对照组(P<0.05);治疗组的临床总有效率达到100.0%,显著高于对照组的89.8%,组间比较差异有统计学意义(P<0.05)。结论维生素D佐治病毒性肺炎临床疗效满意,具有一定临床推广价值。

Objective TO investigate the clinical efficacy of vitamin D in the treatment of children with viral pneumonia.Methods 118 children with viral pneumonia were randomized into the study group and control group,with 59 patients in each group.The control group was applied conventional anti-viral therapy（ Ribavirin 10 mg / kg. d bid） and symptomatic treatment,while the study group applied vitamin D drops based on the control group,1week for a period of treatment. Results After treatment,the levels of 25-（ OH） D3 and Ig A of study group were significantly better than those of control group（ P 0. 05）; After treatment,the Total clinical efficiency rate of study group was significantly higher than that of control group（ P 0. 05）. Conclusion vitamin D in the treatment of children with viral pneumonia can improve the treatment effect. It is worthy to be used in clinical.