西酞普兰联合降压药治疗原发性高血压伴焦虑抑郁患者疗效观察

Therapeutic effect observation on citalopram combined with antihypertensive drugs for treating patients with essential hypertension complicating anxiety depression

目的探讨降压药物联合西酞普兰治疗原发性高血压伴焦虑抑郁患者的疗效及安全性。方法随机将2012年2月至2014年8月重庆市第十三人民医院收治的64例原发性高血压患者分为观察组和对照组,每组32例。观察组接受常规降压药物联合西酞普兰治疗,对照组接受常规降压药物治疗,均治疗6周,观察两组患者血压变化、汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分变化、不良反应发生情况等。结果治疗后两组患者血压、HAMA评分和HAMD评分均下降,观察组有效率[90.62%(29/32)]高于对照组[65.62%(21/32)],HAMD、HAMA总分[分别为(7.12±4.21)、(10.4±7.2)分]低于对照组[分别为(17.42±4.37)、(15.1±7.9)分],差异均有统计学意义(P<0.05)。结论西酞普兰联合降压药物治疗原发性高血压伴焦虑抑郁效果良好,能改善患者情绪,提高降压效果,且未发生明显不良反应。

Objective To investigate the curative effect and safety of antihypertensive drugs combined with citalopram for the treatment of the patients with essential hypertension（EH） complicating anxiety depression. Methods Sixty-four patients with EH in the Chongqing Municipal Thirteenth People′s Hospital from February 2012 to August 2014 were randomly divided into the observation group and the control group,32 cases in each group. The observation group received the routine antihypertensive drugs combined with citalopram,while the control group received the therapy of routine antihypertensive drugs. The treatment lasted for 6 weeks in the two groups. The changes of blood pressure,scores of Hamilton anxiety scale（HAMA） and Hamilton depression scale（HAMD） and occurrence situation of adverse reactions were observed in the two groups. Results The blood pressure,HAMD and HAMA scores after treatment in the two groups were dropped,the effective rate in the observation group reached 90.62%（29/32）,which was higher than 65.62%（21/32） in the control group. The HAMD and HAMA total scores in the observation group were（7.12 ±4.21）points and（10.4 ±7.2）points,which were lower than（17.42 ±4.37） points and（15.1 ±7.9）points in the control group with statistical differences（P〈0.05）. Conclusion Citalopram combined with antihypertensive drugs for treating EH complicating anxiety depression has better effect,can improve the mood of patients and increases the antihypertensive effect without obvious adverse reactions occurrence.