摘要
以Cu I为催化剂,芳胺与多氟苯经重氮化/偶联一锅反应合成了6个多氟取代的联苯类化合物(3a^3f),收率56%~82%,其结构经1H NMR,19F NMR和EI-MS确证。在最佳反应条件[1a 2 mmol,20%Cu I为催化剂,150%四丁基碘化铵为碘化试剂,V(DMSO)∶V(Me CN)=1∶1为溶剂,于130℃反应4 h]下,3a收率75%。
A new one-pot synthetic method to prepare multiple fluorine substituted biaryl compounds( 3a ~ 3f) by diazotization /cross-coupling of aromatic anilines with polyuoroarenes had been developed. The yields were 56% ~ 82%. The structures were confirmed by1 H NMR,19 F NMR and EIMS. Under the optimized conditions[1a 2 mmol,20% Cu I as the catalyst,150% Bu4 NI as the iodide reagent,V( DMSO) ∶ V( Me CN) = 1 ∶ 1 as the solvent,at 130 ℃ for 4 h],the yield of 3a was 75%.
出处
《合成化学》
CAS
CSCD
2016年第3期259-262,共4页
Chinese Journal of Synthetic Chemistry
关键词
偶联反应
重氮化反应
多氟联苯
合成
coupling reaction
diazotization
fluorobiphenyl
synthesis