GP化疗方案治疗高龄非小细胞肺癌的临床疗效观察

Clinical Effect of GP Chemotherapy Regimen in the Treatment of Elderly Patients With Non-small Cell Lung Cancer

目的观察GP化疗方案治疗高龄非小细胞肺癌的临床疗效。方法选择2009年1月—2013年1月潍坊市中医院收治的高龄非小细胞肺癌患者80例,按照随机数字表法分为观察组和对照组,每组40例。患者入院后均行常规开胸手术切除病灶,术后对照组患者给予NP化疗方案(长春瑞滨+顺铂),观察组患者给予GP化疗方案(吉西他滨+顺铂)。3周为1个化疗周期,两组患者治疗4个化疗周期。比较两组患者临床疗效、毒副作用发生情况及6、12个月生存率。结果观察组患者临床疗效优于对照组(Z=2.140,P<0.05)。两组患者白细胞计数减少、贫血、血小板计数减少、恶心呕吐、皮疹、乏力、脱发、中性粒细胞分数减少发生率比较,差异无统计学意义(P>0.05)。两组患者6个月生存率比较,差异无统计学意义(P>0.05);观察组患者12个月生存率高于对照组(P<0.05)。结论高龄非小细胞肺癌患者术后采用GP化疗方案进行治疗的临床疗效确切,毒副作用较少,近期生存率较高。

Objective To observe the clinical effect of GP chemotherapy regimen in the treatment of elderly patients with non- small cell lung cancer. Methods A total of 80 elderly patients with non- small cell lung cancer were selected in the Traditional Chinese Medicine Hospital of Weifang from January 2009 to January 2013,and they were divided into control group and observation group according to random number table, each of 40 cases. Based on conventional thoracotomy for lesion resection,patients of control group received NP chemotherapy regimen（ navelbine ＋ cisplatin）,while patients of observation group received GP chemotherapy regimen（ gemcitabine ＋ cisplatin）; both groups treated for 4 cycles of chemotherapy（ 3 weeks as a cycle of chemotherapy）. Clinical effect, incidence of toxic and side effects and 6-,12- month survival rate were compared between the two groups. Results The clinical effect of observation group was statistically significantly better than that of control group（ Z = 2. 140,P〈0. 05）. No statistically significant differences of incidence of WBC reducation,anemia,PLT reducation,nausea or vomiting,rash,lacking in strength,baldness or neutrophil count reducation was found between the two groups（ P〈0. 05）. No statistically significant differences of 6- month survival rate was found between the two groups（ P〉0. 05）,while 12- month survival rate of observation group was statistically significantly higher than that of control group（ P〈0. 05）. Conclusion GP chemotherapy regimen has certain clinical effect in the treatment of elderly patients with non- small cell lung cancer,the incidence of toxic and side effects is relatively low,while the short- term survival rate is relatively high.