摘要
目的 :探讨使用尖吻蝮蛇血凝酶对行扁桃体切除术患者进行术后止血的安全性。方法 :选取近年来在我院进行扁桃体切除术的30例患者作为研究对象。在术前及术中不对患者进行用药。术后根据患者手术创面的实际情况,为其使用尖吻蝮蛇血凝酶进行止血。然后,对所有患者的生命体征、进行心电图检查的结果、凝血功能指标、血常规检查指标、肝功能指标和肾功能指标的变化情况进行比较。结果 :与术前相比,这30例患者在术毕用药后其生命体征、进行心电图检查的结果、肝功能指标、肾功能指标、凝血功能指标及其血常规检查中RBC的水平、HGB的水平及PLT的水平均未发生明显的变化,差异不显著(P>0.05),无统计学意义。与术前相比,这些患者术毕用药后其WBC的水平有所增高,差异显著(P<0.05),有统计学意义。结论 :使用尖吻蝮蛇血凝酶对实施扁桃体切除术的患者进行术后止血的安全性较高。此法值得在临床上推广应用。
Objective To evaluate the safety of hemocoagulase agkistrodon（HCA）application after tonsillectomy. Methods According to the self-control method,30 patients were without hemostatic before operation and during operation,administrated haemocoagulase agkistrodon 2 U with 1 to 3 days after surgery,as the situation.The coagulation function and safety were observed index before operation and after administration in 24 h,respectively.Results The body coagulation parameters and safety indexes were similar between two groups（except for WBC）.There were no adverse events occurred.Conclusion The application of haemoeoagulase agkistrodon after tonsillectomy is safe.
