肺型氧中毒的研究进展

Research progress of research of pulmonary oxygen toxicity

高浓度氧已被广泛用于多种疾病的治疗以及潜水作业等特殊环境中,并发挥了难以替代的作用,但氧中毒是与之相伴的一个重要并发症,尤其是在潜水医学中,肺型氧中毒已经成为常见的严重问题。由于肺脏自身的特点及干性/湿性环境的差异,肺型氧中毒的病理机制异常复杂。随着实验技术的进步及研究思路的拓展,关于肺型氧中毒的研究已不再局限于组织形态及病理水平阶段,更多的细胞水平及亚细胞水平的研究已取得一定成果。本文针对肺型氧中毒的临床表现、病理生理、发病机制及近年来的检测和治疗进展进行综述。

Hyperbaric oxygen has been widely used in the treatment of many diseases and in some special circumstances such as deepwater diving, and it plays an irreplaceable role. But oxygen toxicity is an important complication, especially in diving medicine. Due to the characteristics of lung itself and the differences in dr y/wet environment, the pathological mechanism of pulmonary oxygen toxicity is very complicated. With the advances in the experimental techniques and expansion of the research ideas, the studies on pulmonary oxygen toxicity have no longer limited to the level of tissue morphology and pathological strata, more and more studies that focused on cellular and sub-cellular levels have been carried out. The present review will focus mainly on the clinical manifestations, pathophysiology, pathogenesis and progresses in monitoring and treatment of pulmonary oxygen toxicity over recent years.