天然黄酮类单体化合物抗焦虑作用研究进展

Advanced in studies on anxiolytic effects of natural flavonoids

焦虑症是严重危害人类健康的常见疾病之一,其发病机制十分复杂,国内外对焦虑症机制的研究多集中在神经递质、神经内分泌和免疫系统。近年来,对天然黄酮类单体化合物抗焦虑作用的研究日渐增多,但研究内容仍较少且不系统,研究方向仅仅涉及几种神经递质。该文将从黄酮类单体化合物抗焦虑的不同作用机制出发,对国内外天然黄酮类单体化合物抗焦虑作用及其机制、构效关系研究进行综述,为黄酮类单体化合物抗焦虑作用机制的深入研究,以及该类药物的开发研制提供理论依据。

Anxiety is one of the most common diseases endangering human health. Its pathogenesis is complex,the studies on the mechanisms of anxiety disorder are concentrated on neurotransmitter,neuroendocrine,immunologic system. Flavonoids are a kind of compounds which possess a variety of physiological activity,used in plenty of diseases. In recent years,researches of natural flavonoids on anti-anxiety were increasing,but contents were incomplete. It was just involved several neurotransmitters in research area. This paper is based on different anxiolytic effect mechanisms and structure-activity relationships of natural flavonoids,summarizing the researches of domestic and foreign,which can serve as a reference for further studies on anxiolytic effects of natural flavonoids.