冷水七的化学成分研究

Chemical constituents from Impatiens pritzllii var. hupehensis

通过正丁醇萃取、硅胶柱色谱、Sephadex LH-20以及HPLC等色谱手段对凤仙花科凤仙花属植物冷水七的50%乙醇提取物进行分离纯化,并结合1D-NMR,2D-NMR,HRESI-MS等数据进行结构鉴定。共分离鉴定8个化合物,1为新化合物,命名为2,6-dimethyl-2-vinyl-2,3,4,7-tetrahydrooxepine(1),其余7个为已知化合物,分别是1,3,6-trihydroxy-7-methyl-anthraquinone(2),4-hydroxybenzaldehyde(3),4-(3-methoxy-4-hydroxyphenyl)-2-butanone(4),podophyllotoxin(5),scopoletin(6),α-spinasterol(7)和3-O-β-D-glucopyranosyl-α-spinasterol(8)。以上已知化合物均为首次从该植物中分离得到。

Eight compounds were isolated from the 50% ethanol extract of Impatiens pritzllii var. hupehensis through various column chromatography methods including silica gel,Sephadex LH-20,and preparative HPLC. Their structures were elucidated as 2,6-dimethyl-2-vinyl-2,3,4,7-tetrahydrooxepine（ 1）,1,3,6-trihydroxy-7-methyl-anthraquinone（ 2）,4-hydroxybenzaldehyde（ 3）,4-（ 3-methoxy-4-hydroxyphenyl）-2-butanone（ 4）,podophyllotoxin（ 5）,scopoletin（ 6）,α-spinasterol（ 7） and 3-O-β-D-glucopyranosyl-α-spinasterol（ 8） based on the NMR and MS spectral data. Compound 1 is new compound and compounds 2-8 are isolated from this plant for the first time.