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4-甲基和4-三氟甲基烟酸的合成工艺研究 被引量：1

Study on the synthesis of 4-methylnicotinic acid and 4-( trifluoromethyl) nicotinic acid
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摘要 以乙酰乙酸乙酯和三氟乙酰乙酸乙酯与氰基乙酰胺为原料,经环化、氯化、水解、催化氢解脱卤得目标产物4-甲基烟酸和4-三氟甲基烟酸,中间体及目标产物结构由IR,MS和1H-NMR表征。 4-Methylnicotinic acid and 4-（ trifluoromethyl） nicotinic acid were synthesized from ethyl 3-oxobutanoate and ethyl 4,4,4-trifluoro-3-oxobutanoate with 2-cyanoacetamide by cyclization,chlorination,hydrolysis and then catalytic hydogennation. The structures of target compounds were characterized by IR,MS and ^1H-NMR.
作者 王雪丁 杨维清 邹浩 蒋兴军 余婷 马梦林
机构地区 西华大学理学院
出处 《化学研究与应用》 CAS CSCD 北大核心 2016年第3期404-407,共4页 Chemical Research and Application
基金 四川省教育厅青年基金项目(P0210501)资助 西华大学研究生创新基金项目(ycjj2015049)资助
关键词 乙酰乙酸乙酯 三氟乙酰乙酸乙酯 4-甲基烟酸 4-三氟甲基烟酸 合成 ethyl 3-oxobutanoate ethyl 4 4 4-trifluoro-3-oxobutanoate 4-methyl nicotinic 4-（trifluoromethyl） nicotinic synthesis
分类号 O626.32 [理学—有机化学]
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参考文献11

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化学研究与应用
2016年 第3期

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