23例大疱性类天疱疮回顾性临床分析

Retrospective clinical analysis of 23 patients with bullous pemphigoid

目的总结大疱性类天疱疮的临床特点及治疗经验。方法回顾性分析2013年4月至2014年4月在我院皮肤科住院治疗的23例大疱性类天疱疮患者入院时的一般情况、实验室检查及临床疗效。结果轻、中度患者激素控制剂量(以泼尼松为标准量)分别为0.72±0.11mg/kg·d、1.35±0.40mg/kg·d,差异均有统计学意义(P<0.01)。无粘膜受累组与粘膜受累组患者激素控制剂量分别为1.38±0.45mg/kg·d、2.01±0.37mg/kg·d,差异有统计学意义(P<0.01)。结论大疱性类天疱疮患者的激素治疗不良反应发生率高,应权衡利弊,以获得最佳收益。

Objective To summarize the clinical features and effective treatment for bullous pemphigoid.Methods To retrospectively analyze the clinical data of 23 cases with bullous pemphigoid from April 2013 to April 2014 in department of dermatology,Binzhou Medical University Affiliated Hospital.Results The dose of corticosteroids was 0.72±0.11 mg/kg·d and1.35±0.40mg/kg·d based on baseline affected BSA of less than 30%,30%-50%,respectively.The dose of corticosteroids was 1.38±0.45mg/kg·d and 2.01±0.37mg/kg·d,based on whether the mucosal lesions occurred（P〈0.01）.Conclusion The hormonotherapy has a higher rate of adverse reaction,so we should choose a proper treatment for the patients with bullous pemphigoid to get the best returns.