Wnt/β-catenin通路在动脉粥样硬化发生发展中的作用

Role of Wnt/β-catenin signaling pathway in atherosclerosis

动脉粥样硬化（atherosclerosis,AS）作为心血管疾病（cardiovascular disease,CVD）的主要病理基础,严重危害人们的健康~[1]。AS是多因素、多发病环节参与的慢性炎症性疾病,内皮损伤和功能减退是其发生的启动环节,炎症细胞浸润和炎症介质释放、氧化应激反应、血管平滑肌细胞增殖以及泡沫细胞形成和死亡是AS发生发展的关键机制。

Atherosclerosis is a multifactorial process associated with endothelial cell injury and dysfunction,inflammation,oxidative stress,cell proliferation,angiogenesis and so on,all of which play a crucial role in atherosclerosis.Wnt/β-catenin signaling pathway is highly conservative in the development of body,abnormal activation of which is related to types of diseases including cancer.Accumulating studies have shown that Wnt/β-catenin signaling pathway is involved in inflammation,oxidative stress and so on.This article would make a review about the role of Wnt/β-catenin signaling pathway in atherosclerosis based on the pathogenic mechanisms underlying atherosclerosis as mentioned above.