宫颈小细胞癌细胞学与组织病理学分析并文献复习

Cytological and histological features of small cell carcinoma of the cervix:a case report and review of the literature

目的探讨宫颈小细胞癌(SCCC)的细胞学和组织病理学特点、免疫组织化学及鉴别诊断。方法对1例SCCC进行细胞形态学、组织病理形态学、免疫组织化学观察和文献复习。结果 SCCC传统涂片特点为肿瘤细胞呈圆形或卵圆形,排列紧密,相互挤压变形,胞浆稀少,边界不清,核浆比例高,染色质细腻,核仁不明显。组织学特点为肿瘤细胞为形态一致的小细胞区,细胞散在﹑呈片状或梁索状,浸润性生长。免疫组织化学:CK(+)、CgA(+++)、Syn(+++)、Ki-67约25%(+);CerbB-2(-)、p63(-)、CK5/6(-)、LCA(-)。结论SCCC是一种少见的高度恶性肿瘤,具有特征性的细胞﹑组织学改变。

Objective To study the cytological,histological and immunohistochemical features of small cell carcinoma of the cervix（SCCC）and its differential diagnosis.Methods A case of SCCC was reviewed in terms of its cytological,histological and immunohistochemical features with the help of related data and literatures.Results Cytological smear of SCCC showed that the tumor cells were round or orbicular-ovate,with a high karyoplasmic ratio and fine chromatin,but cytoplasm is scarce and no obvious nucleus was found.SCCC cytology also revealed that tumor cells were deformed and densely packed with an indistinct intercellular boundary due to squeezing.The histological characteristic was that the tumor cells had a uniformly small size with an infiltrative growth pattern.Tumor cells were distributed dispersedly or formed nesting and trabeculation.Immunohistochemistry showed tumor cells were CK（＋）,CgA（＋＋ ＋）,Syn（＋ ＋ ＋）,CerbB-2（-）,p63（-）,CK5/6（-）and LCA（-）,while 25% tumor cells were Ki-67（＋）.Conclusion SCCC is a kind of very rare and highly malignant tumor,which has characteristically cytological and histological pattern.