新型七甲川菁染料用作肿瘤模型活体成像的研究进展

Advances in research of novel heptamethine cyanine dyes as a potential diagnostic agent for optical imaging of tumor models

一种近红外荧光(NIRF)七甲川菁染料不需要化学修饰,可直接被肿瘤细胞吸收呈特异性聚集,从而可用于肿瘤活体成像。这种染料在肿瘤细胞与正常细胞之间的摄取差异可能是由于特异型有机阴离子转运肽的作用,并受到低氧条件控制。这些特性将会拓展NIRF类染料在肿瘤成像研究中的应用。

A class of near infrared fluorescence（ NIRF） heptamethine cyanine dyes,in their native form without chemical conjugation,can be taken up and accumulated specifically in cancer cells and used for tumors imaging. The different uptake of the dyes into cancer but not normal cells is possible due to the presence of specific isoforms of organic anion-transporting peptides（ OATPs）,and regulated by hypoxia. These advances have widely extended current application of NIRF imaging in cancer diagnosis.