辛伐他汀联合曲美他嗪健心胶囊对慢性心衰患者心功能指标的影响

Effect of Simvastatin Combined with Trimetazidine and Jianxin Capsule in Treatment of Chronic Heart Failure and its Influence on Heart Function Index

目的:探讨辛伐他汀联合曲美他嗪、健心胶囊治疗慢性心衰的疗效及其对心功能指标的影响。方法:将192例慢性心衰患者随机分为观察组与对照组,每组各96例,对照组用辛伐他汀治疗,观察组用辛伐他汀联合曲美他嗪、健心胶囊治疗,治疗期间观察各组患者心功能指标、血脂水平、6min步行试验、心率,疗程均为6个月。结果:治疗后,观察组总有效率(96.88%)显著高于对照组(76.04%,P<0.01)。治疗前心率差异无统计学意义。治疗后,两组心率均较治疗前降低,(均P<0.05),观察组降幅较对照组更为显著(P<0.05)。两组左室收缩末期内径(LVESD)、左心室舒张末内径(LVEDD)、治疗前左室射血分数(LVEF)治疗前比较差异无统计学意义。治疗后,两组心功能指标较治疗前均有不同程度的改善(均P<0.05),观察组较对照组改善明显(P<0.05)。治疗前两组6min步行试验比较,差异无统计学意义。两组LDL-C、HDL-C、TC、TG治疗前比较无统计学意义(P>0.05);两组LDL-C、TC、TG治疗后显著低于各组间治疗前(P<0.05),而HDL-C治疗后显著高于各组间治疗前(P<0.05);观察组较对照组改善明显(P<0.05)。治疗后,两组6min步行试验较治疗前均有改善(均P<0.01),其中观察组改善明显好于对照组(P<0.05)。治疗后,两组心率均较治疗前降低,(均P<0.05),观察组降幅较对照组更为显著(P<0.05)。结论:辛伐他汀联合曲美他嗪和健心胶囊治疗慢性心衰患者,可获得协同的降压效应,并可改善心力衰竭患者的心功能。

Objective： To explore the effect of simvastatin combined with trimetazidine and Jianxin capsule in treatment of chronic heart failure and its influence on heart function index. Method： 192 cases wtih chronic heart failure patients were randomly divided into two groups： observation group and control group,with96 cases in each group. The patients in the control group were treated with simvastatin,and the observation group with simvastatin,combined with trimetazidine and Jianxin capsule. During 6 months of treatment,the observations were made about serum lipid level,heart rate,heart function index,and 6-minute walk test.Results： After treatment,the total effective rate in the observation group（ 96. 88%） was significantly higher than that in the control group（ 76. 04%）,（ P〈0. 01）. Heart rate difference was not statistically significant before treatment. After treatment,the heart rates of two groups were lower than those before treatment（ P〈0.05）,but the observation group showed a greater decline extent than the control group（ P〈0. 05）. Before treatment,LVESD,LVEDD,LVEF differences had no statistical significance between the two groups. After treatment,the indexes of heart function in two groups showed different degree of improvement（ P〈0. 05）,but more sinificant in the observation group than in the control group（ P〈0. 05）. Before treatment,the difference in 6min walking test was not statistically significant. And nor were the differences in LDL-C、HDL-C、TC、TG in two groups（ P〈0. 05）; LDL-C、TC and TG were much lower than before treatment,while HDL-C was much higher（ P〈0. 05）. The observation group showed more significant improvement than the control group（ P〈0. 05）. The 6min walking test in the two groups were both improved than before,and the improvement in the observation group was much better than that in the control group（ P〈0. 05）. Heart rate in the two groups both decreased than before（ P〈0. 05）,and observation group showed more significant decline than control group（ P〈0. 05）. Conclusion： Simvastatin combined with trimetazidine and Jianxin capsule in treatment of chronic heart failure can obtain the hypotensive effect of synergy,and improve the heart function in patients with heart failure.