子痫前期患者肾功能的评价及临床意义

Evaluation and Clinical Significance of Renal Function in Patients with Preeclampsia

目的:探究子痫前期患者肾功能的评价及其临床意义分析。方法:选取2013年1月至2014年12月收治的84例子痫前期患者作为观察组,其中轻度子痫前期患者50例,重度子痫前期患者34例,另选取同期来我院进行产前体检的正常孕妇50例作为对照组,分析两组患者肾功能指标的差异以及临床意义。结果:子痫前期患者血肌酐、24h尿蛋白、血尿素氮以及UA的水平均显著高于对照组孕妇,且随着病情的加重,各项指标的水平也显著上升,子痫前期组孕妇肾功能参数异常的发生率要显著高于对照组孕妇,肾功能参数异常组的孕妇其围产儿不良结局发生率要明显高于肾功能参数正常组孕妇,以上差异均有明显的统计学价值(P<0.05)。各肾功能指标与围产儿不良结局均呈正相关,与血肌酐相关系数最高(r=0.74,P<0.01)。结论:血清UA等肾功能指标的水平能够作为判断子痫前期患者病情的严重程度以及围产儿不良结局的重要预测指标,有明显的临床价值。

Objective： To investigate the evaluation and clinical significance in patients with preeclampisa. Method： 84 patients with preeclampsia who were in hospital from January 2013 to December 2014 were selected as observation group,including to patients with mild preeclampsia and 34 patients with severe preeclampsia. 50 cases of normal pregnant women in the same time were selected as the control group. The differences of renal function and clinical significance of the two groups were analyzed. Result： Serum creatinine,24 h urine protein,blood urea nitrogen and UA levels in observation group were significantly higher than those in the control group,and with the increase of the severity of the disease,the incidence of renal function parameters in observation group was significantly higher than that in the control group,the difference was statistically significant（ P〈0. 05）. The renal function indexes were positively correlated with the adverse outcome of the perinatal fetus,and the correlation coefficient was the highest（ r = 0. 74,P〈0. 01）. Conclusion： The levels of serum UA and other renal function indicators can be used as an important index to determine the severity of preeclampsia and perinatal outcomes. It has significient clinical value.