针刺治疗对原发性痛经患者性激素及前列腺素分泌的调节作用

Regulating effect of acupuncture therapy for secretion of sex hormone and prostaglandin of patients with primary dysmenorrhea

目的评价针刺治疗对原发性痛经患者性激素及前列腺素分泌的调节作用。方法选取2013年10月2015年1月于邯郸明仁医院就诊的150例原发性痛经患者,将其随机分为对照组（n=75）和治疗组（n=75）,对照组患者口服少腹逐瘀汤,治疗组除口服少腹逐瘀汤外还给予针刺治疗。1个月经周期为1个疗程,3个疗程后评价临床疗效。观察两组治疗前后血清性激素[雌二醇（E2）、孕酮（P）]、前列腺素[前列腺素E2（PGE2）、前列腺素F2α（PGF2α）]变化。结果 1治疗后,治疗组总有效率（89.33%）显著高于对照组（76.00%）,差异有高度统计学意义（P〈0.01）。2两组治疗前性激素水平比较差异无统计学意义（P〉0.05）。与治疗前比较,治疗后两组E2水平降低,P水平升高,差异均有高度统计学意义（P〈0.01）。其中治疗组E2水平由治疗前的（42.25±12.31）pg/mL下降至治疗后的（36.05±10.33）pg/mL,而P水平由治疗前的（0.69±0.64）ng/m L上升至治疗后的（0.75±0.34）ng/m L,治疗组治疗后E2、P水平与对照组比较差异有高度统计学意义（P〈0.01）。3两组治疗前血清中前列腺素水平比较差异无统计学意义（P〉0.05）,治疗后两组患者PGE2水平明显升高（P〈0.01）,而PGF2α水平和PGF2α/PGE2水平显著降低（P〈0.01）。治疗后,治疗组前列腺素水平的恢复效果优于对照组,差异有高度统计学意义（P〈0.01）。结论针刺疗法可调节原发性痛经患者的激素水平,改善痛经症状,临床效果明显,值得进一步推广。

Objective To evaluate the regulating effect of acupuncture therapy for secretion of sex hormone and prostaglandin of patients with primary dysmenorrhea. Methods One hundred and fifty patients with primary dysmenorrhea treated in Handan Mingren Hospital from October 2013 to January 2015 were selected and randomly divided into control group（n = 75） and treatment group（n = 75）, the control group was given Shaofu Zhuyu Decoction orally, while the treatment group was given acupuncture therapy except for Shaofu Zhuyu Decoction, one menstrual cycle was as a course, the clinical effect was evaluated after treatment for three courses. The changes of sex hormone [estradiol（E2）, progesterone（P）] and prostaglandin [prostaglandin E2（PGE2）, prostaglandin F2α（PGF2α）] in the two groups before and after treatment were observed. Results 1After treatment, the total effective rate of treatment group（89.33%） was higher than that of control group（76.00%）, the difference was highly statistically significant（P 〈 0.01）. 2There were no significant differences of sex hormone levels before treatment between the two groups（P 〉 0.05）. Compared with before treatment,the levels of E2 after treatment in the two groups were decreased, the levels of P were increased, the differences were highly statistically significant（P 〈 0.01）. The level of E2 in the treatment group decreased from（42.25±12.31） pg/m L before treatment to（36.05±10.33） pg/m L after treatment, while the level of P increased from（0.69 ±0.64） ng/m L before treatment to（0.75±0.34） ng/m L after treatment. There were highly statistically significant differences of E2, P levels after treatment between treatment group and control group（P 〈 0.01）. 3 There were no significant differences of prostaglandin levels before treatment between the two groups（P 〉 0.05）. After treatment, the levels of PGE2 in the two levels of PGF2α and PGF2α/PGE2 were decreased significantly（P 〈 0.01）. After treatment, the restoring effect of prostaglandin levels in the treatment group was better than that of control group, the difference was highly statistically significant（P 〈 0.01）. Conclusion Acupuncture therapy can regulate the hormone levels of patients with primary dysmenorrhea, improve dysmenorrhea symptoms, the clinical effect is obvious, which is worthy of further promotion.