急性脑梗死患者血尿酸、同型半胱氨酸水平与颈动脉斑块稳定性的相关性分析

Analysis the relationship between uric acid and homocysteine level and carotid artery plaque stability of patients with acute cerebral infarction

目的 探讨血尿酸、同型半胱氨酸水平与急性脑梗死患者颈动脉斑块稳定性的关系。方法 选取2014年1月~2015年6月我院108例急性脑梗死患者作为研究对象,根据颈动脉超声检查结果将其分为稳定斑块组和不稳定斑块组,抽取两组患者静脉血检测血尿酸和同型半胱氨酸的水平,并进行比较。结果 108例患者的不稳定斑块发生率为38.0%,血尿酸和同型半胱氨酸的平均水平分别为（330.94±88.21）mmol/L和（16.92±4.60）μmol/L。不稳定斑块组的血尿酸和同型半胱氨酸水平最高,分别为（373.13±81.37）mmol/L和（20.25±3.12）μmol/L;稳定斑块组其次,分别为（326.79±74.46）mmol/L和（16.57±4.03）μmol/L;无斑块组最低,分别为（285.31±85.64）mmol/L和（13.35±3.75）μmol/L（P〈0.05）。伴有高尿酸血症或高同型半胱氨酸血症患者的不稳定斑块发生率分别为54.0%、52.2%,高于尿酸或同型半胱氨酸水平正常的患者,分别为29.6%、12.8%（P〈0.05）。结论 急性脑梗死患者血尿酸、同型半胱氨酸水平与急性脑梗死患者的颈动脉斑块稳定性呈正相关。

Objective To explore the relationship between uric acid and homocysteine level and carotid artery plaque stability of patients with acute cerebral infarction..Methods 108 patients with acute cerebral infarction in our hospital from January 2014 to June 2015 were selected as study objects and were divided into stable plaque group and unstab!e plaque group according to results of carotid artery uhrasonography.The level of uric acid and homocysteine were de- ceted by extrecting patients＇ venous blood and then compared. Results The incidednce rate of unstable plaque among 108 Patiehts was 38.0%,the averge level of uric acid and homocysteine was respectively （330.94±88.21） mmol/L and （16.92±4.60） μmol/L.The level of uric acid and homocysteine in unstable plaque group was the highest,which was re- spectively （373.13±81.37） mmol/L and （20,25±3.12） mmol/L;The stable group was followed respectively （326.79± 74.46） mmoi/L and （16.57±4.03） μmol/L,and the non-plaque group was the lowest,which was respectively （285.31± 85.64） mmol/L and （13.35±3.75） μmol/L（P〈0.05）.The incidence rate of unstable plaque of patients with hyperuricemia or hyperhomocysteinemia was respectively 54.0% and 52.2%,higher than that was respectively 29.6% and 12.8% in patients with normal uric acid and homocysteine level （P〈0.05）. Conclusion The uric acid and homocysteine level of acute ＇cerebral infarction patients has positive relationship with carotid artery plaque stability.