布地奈德鼻腔雾化联合口服氯雷他定治疗中重度持续性变应性鼻炎的效果

Effect of budesonide suspension nasal spray cornbined with loratadine in treating moderately severe persistent allergic rhinitis

目的 探索布地奈德（BUD）鼻腔雾化联合口服氯雷他定治疗中重度持续性变应性鼻炎（AR）的疗效。方法 选择2013年6月~2014年10月来我院就诊的30例对常规治疗（鼻喷激素和抗组胺药）不满意的中重度持续性AR患者,将其随机分为两组,治疗组（n=15）给予BUD鼻腔雾化,对照组（n=15）采取生理盐水鼻腔雾化,1次/d,持续治疗14 d。两组均给予氯雷他定口服。分别于开始治疗时（基线）和治疗14 d后对临床症状进行评估。结果 与基线比较,治疗组治疗后鼻塞、流涕、鼻痒和喷嚏的评分均显著下降（P=0.000）;对照组喷嚏评分显著下降（P=0.004）,其他症状评分与基线比较差异无统计学意义（P〉0.05）。在各症状的改善程度上,治疗组均显著优于对照组（P〈0.01）。结论 BUD雾化联合氯雷他定口服对于常规治疗无效的中重度持续性AR,在症状控制上能取得较为满意的效果。

Objective To explore the effect of budesonide suspension （BUD） nasal spray combined with loratadine in treating moderately severe persistent allergic rhinitis （AR）. Methods 30 patients with moderately severe persistent AR who were not satisfact to the routine treatment in our hospital from June 2013 to October 2014 were recorded,and were randomly divided into two groups.Patients in treatment group were given BUD nasal spray and patients in control group were given saline nasal spray,once a day for 14 days.All patients in two groups were given oral loratadine.The clinical symptoms were evaluated at pro-treatment （baseline） and after 14 days for treatment respectively. Results Compared with baseline,the score of nasal congestion,running nose,sneeze and rhinocnesmus in treatment group after treatment decreased obvious（P=0.000）,the score of sneeze decreased obvious in control group（P=0.004）,while other symptoms had no obvious difference （P〉0.05）.On the improvement degree of each symptoms,the treatment group was obvious higher than that of control group respectively （P〈0.01）. Conclusion For moderately severe persistent allergic rhinitis that con- ventional treatment is invalid,BUD nasal spray combined with oral loratadine can get more satisfactory results in control symptoms.