门控心肌灌注显像评价左心室功能的Meta分析

Review of left ventricular function with gated myocardial perfusion imaging: a Meta-analysis

目的评价门控心肌灌注显像（G-SPECT）和超声心动图（ECHO）诊断左心室功能的有效性。方法计算机辅以人工检索Pub Med、EMbase、CBMdisc、VIP、CNKI数据库,检索时间2000年1月~2015年1月,纳入中外公开发表的关于G-SPECT与ECHO诊断左心室功能的相关研究。由两名评价者独立按纳入、剔除标准,筛选文献,提取数据,交叉核对,采用Stata12.0软件进行Meta分析。结果共纳入19个研究,1051例患者。结果显示：与ECHO比较,G-SPECT在诊断左室射血分数（WMD=-0.92,95%CI：-2.95~1.114,P=0.38）和左室舒张末期容积（WMD=6.59,95%CI：-4.76~17.94,P=0.26）方面,两组差异无统计学意义;在评价左室收缩末期容积方面,两组差异有统计学意义（WMD=8.21,95%CI：0.23~16.19,P=0.04）。结论当前证据表明,在诊断左心室射血分数和舒张末期容积效能上G-SPECT与ECHO相仿,而在评价收缩末期容积方面G-SPECT优于ECHO。

Objective To review the effectiveness of gated myocardial perfusion imaging（G-SPECT） and echocardiogram（ECHO） in diagnosis of left ventricular function. Methods The databases of Pub Med, EMbase, CBMdisc, VIP and CNKI were retrieved with computer supplemented by artificial retrieving from Jan. 2000 to Jan. 2015, and published studies related to G-SPECT and ECHO in diagnosis of left ventricular function were chosen. The documents were selected according to inclusion and exclusion criteria and data was extracted and checked crossly by 2 reviewers independently. The data was given a Meta-analysis by using Stata12.0 software. ResultsThere were totally 19 studies included involving 1051 cases. The results of Meta-analysis showed that ECHO and G-SPECT had no statistical difference in reviewing left ventricular ejection fraction（LVEF, WMD=-0.92, 95%CI：-2.95~1.114, P=0.38） and left ventricular end-diastolic volume（LVEDV, WMD=6.59, 95%CI：-4.76~17.94, P=0.26）, and had statistical difference in reviewing left ventricular end-systolic volume（LVESV, WMD=8.21, 95%CI： 0.23~16.19, P=0.04）. Conclusion The current evidence indicates that G-SPECT and ECHO are similar to each other in reviewing LVEF and LVEDV, and G-SPECT is better than ECHO in reviewing LVESV.