乳腺腺样囊性癌临床病理分析并文献复习

Clinical Pathological Analysis and Review of Literature of Adenoid Cystic Carcinoma of the Breast

目的:探讨乳腺腺样囊性癌的临床表现、病理特征及鉴别诊断要点。方法:对本院2009-2014年诊治的3例乳腺腺样囊性癌进行回顾性分析,观察其组织学特点并行免疫组化检测,结合相关文献复习。结果:3例乳腺腺样囊性癌患者临床表现为伴或不伴有疼痛的乳腺单发肿块。该肿瘤在组织结构上可以分为小梁-小管状、筛状及实体状三种类型,并需与一系列乳腺良恶性病变相鉴别,如胶原小体病、浸润性筛状癌、小管癌等。结论:乳腺腺样囊性癌是一种少见的特殊类型的乳腺癌,具有其独特的组织病理学特点,预后较好。

Objective：To investigate the clinical manifestations,pathological features and differential diagnosis of the adenoid cystic carcinoma of the breast.Method：Three cases of the breast adenoid cystic carcinoma treated in our hospital during 2009 to 2014 were retrospectively analyzed,the histological characteristic was observed and immunohistochemical representations was detected and combined with the review of related literatures.Result：The main clinical presentation of all three cases was single mass which presenting occasionally painful.Three basic patterns were trabecular-cribriform,tubular and solid.The tumor should be distinguished from a series of benign and malignant breast diseases,such as collagenous spherulosis,invasive cribriform carcinoma,tubular carcinoma and so on.Conclusion：Adenoid cystic carcinoma of the breast is a rare neoplasm with distinctive histology and excellent prognosis.