晶须化磷酸钙多孔生物活性陶瓷修复犬股骨髁缺损

Wisker-covered porous calcium phosphate ceramics in repair of canine femoral condyle defects

背景:前期研究证实,经晶须化处理的磷酸钙多孔生物活性陶瓷内部微观结构得到一定改变,具有良好的力学性能。目的:进一步观察晶须化磷酸钙多孔生物活性陶瓷修复犬股骨髁缺损的效果。方法:采用占位法制备贯通性良好的磷酸钙多孔生物活性陶瓷,经水热处理法完成材料的晶须化。取15只健康成年比格犬,在双侧股骨外侧髁用电钻制造一直径10 mm、深度10 mm的圆柱状包容性骨缺损,右侧置入晶须化磷酸钙多孔生物活性陶瓷,作为实验组;左侧置入未经过晶须化处理的磷酸钙多孔生物活性陶瓷,作为对照组。置入后第2,4,8,12周分别进行骨缺损区X射线及双能X射线检查。结果与结论:1X射线:随着时间的增加,两组骨缺损与正常骨质周围的界面逐渐模糊、消失,12周时两组骨缺损界面已完全融合,对照组材料部分溶解,实验组材料随着时间增长未见明显溶解,两组不同时间点的X射线评分比较差异无显著性意义。2双能X射线:随着时间的增加,两组骨密度逐渐增加,但两组不同时间点的骨密度比较差异无显著性意义。表明晶须化磷酸钙多孔生物活性陶瓷具有良好修复股骨髁缺损的能力。

BACKGROUND： Previous studies have demonstrated that the internal microstructure of porous calcium phosphate ceramics after the whiskering process has some changes, and obtain good mechanical properties. OBJECTIVE： To further investigate the effect of whisker-covered porous calcium phosphate ceramics in repair of canine femoral condyle defects. METHODS： Highly interconnected porous calcium phosphate ceramics was prepared by placeholder method. The whiskering of the materials was finished by hydrothermal process. Fifteen healthy adult beagle dogs were selected in this study. A 10 mm×10 mm cylindrical inclusive bone defect was made bilaterally on the lateral femoral condyle with a drill. The porous calcium phosphate ceramics after the whiskering process was implanted onto the right femoral condyle as experiment group. The porous calcium phosphate ceramics without the whiskering process was implanted onto the left femoral condyle as control group. At 2, 4, 8, and 12 weeks after implantation, X-ray and dual-energy X-ray test were conducted in the bone defect area respectively. RESULTS AND CONCLUSION：（1） X-ray： With the increase of time, the interface between bone defect and normal bone of two groups gradually blurred, disappeared, and completely fused at 12 weeks. The material in the control group was partially dissolved, while there was no obvious dissolution in the experiment group. No significant difference in the X-ray scores was found between two groups at different time points.（2） Dual-energy X-ray： With the increase of time, the bone mineral density of the two groups both increased gradually, but there was no significant difference in the bone mineral density at different time points between these two groups. These results demonstrate that the porous calcium phosphate ceramics after the whiskering process has good ability to repair the defects of femoral condyle.