酪蛋白磷酸多肽/无定形磷酸钙复合物与氟化钠预防正畸托槽周围的牙釉质脱矿

Casein phosphopeptides/amorphous calcium phosphate compound and fluoride prevent enamel demineralization around orthodontic brackets

背景:临床上,酪蛋白磷酸多肽/无定形磷酸钙复合物与氟化钠均能有效防止釉质脱矿发生和龋坏出现。目的:观察酪蛋白磷酸多肽/无定形磷酸钙复合物与氟化钠在固定正畸矫治过程中对牙釉质脱矿的预防作用,寻求效果好的再矿化试剂。方法:将40颗已粘接好托槽的人离体牙随机分为4组,对照组表面不涂布任何物质,护牙素组表面涂布酪蛋白磷酸多肽/无定形磷酸钙复合物,多乐氟组表面涂布氟化钠,联合组表面同时涂布酪蛋白磷酸多肽/无定形磷酸钙复合物与氟化钠。将4组牙齿进行连续14 d的脱矿-再矿化实验,实验结束后扫描电镜观察牙釉质表面孔隙情况,同时测量各组实验前后的显微硬度变化值。结果与结论:对照组出现明显牙釉质脱矿现象,其他3组牙釉质脱矿现象不明显。护牙素组、多乐氟组、联合组的显微硬度变化值均低于对照组(P<0.05),护牙素组、多乐氟组、联合组间显微硬度变化值比较差异无显著性意义。说明氟化钠、酪蛋白磷酸多肽/无定形磷酸钙复合物及两者同时使用在体外实验中均可防止牙釉质脱矿,促进再矿化,但两者联用并未明显提高预防牙釉质脱矿作用。

BACKGROUND： In clinical practice, both casein phosphopeptides/amorphous calcium phosphate compound and fluoride can effectively prevent the occurrence of enamel demineralization and caries.OBJECTIVE： To investigate the preventive effects of casein phosphopeptides/amorphous calcium phosphate compound and fluoride on enamel demineralization in the orthodontic treatment, so as to seek a remineralization agent with good effect. METHODS： Totally 40 human in vitro teeth which had been well bonded to brackets were randomly divided into four groups： control group（the surface was not coated with any substance）, GC tooth mousse group（the surface was coated with casein phosphopeptides/amorphous calcium phosphate compound）, duraphat group（the surface was coated with fluoride） and combined group（the surface was coated with casein phosphopeptides /amorphous calcium phosphate compound and fluoride）. The enamel surface porosity was observed by scanning electron microscopy after the successive 14-day demineralization-remineralization experiments in these four groups. The change value of microhardness was measured before and after the experiment in each group. RESULTS AND CONCLUSION： There was obvious enamel demineralization in the control group, but not in the other three groups. The change value of microhardness in GC tooth mousse, duraphat and combined groups was lower than that in the control group（P 〈0.05）, and there was no significant difference between GC tooth mousse, duraphat and combined groups. These results demonstrate that fluoride, casein phosphopeptides/amorphous calcium phosphate compound and their combination can prevent enamel demineralization, promote remineralization; however, their combination does not improve the effect of preventing enamel demineralization