整合素β与老年急性肺血栓栓塞症的关系

Relationship between the integrin β and acute pulmonary thromboembolism in elderly patients

目的研究老年急性肺动脉栓塞症(pulmonary thromboembolism,PTE)患者整合素表达水平,分析其差异表达,探讨整合素在老年急性PTE发生发展中的潜在机制。方法连续选取43例老年PTE患者为PTE组;另选25例年龄、性别、基础疾病与之匹配的非PTE患者为对照组。分别检测两组的免疫指标。结果 PTE组NK细胞低于对照组,整合素β2、β3、D-二聚体及FDP水平高丁对照组,有统计学差异(P<0.05)。结论整合素β2、β3在老年急性PTE的发生发展过程中起着重要作用,可能参与肺动脉的血栓形成。

Objective To investigate the integrin 91, 132 and 133 expression in elderly patients with acute pulmonary thromboembolism （PTE） with correlation to the development of acute pulmonary embolism. Methods In this study, forty three elderly patients with acute pulmonary thromboembolism were enrolled as the experimental group and wenty-five pati- ents without PTE as the control group. Flow cytometry was performed to detect the expression of integrin β1, β2 and β3. Results The amount of natural killer cells significantly decreased and the expression levels of integrin β2, β3, D-dimer and FDP significantly increased in PTE patients （P〈0.05）. Conclusions Integrin β2, β3 plays an important role in the de- velopment of acute pulmonary embolism in elderly patients and may be involved in pulmonary thrombus formation.