验方参芪杀白汤联合化疗治疗急性髓细胞白血病临床观察

Clinical Observation of Proved Recipe Shenqi Shabai Decoction Combined with Chemotherapy on Acute Myelocytic Leukemia

目的观察验方参芪杀白汤联合化疗治疗急性髓细胞白血病的临床疗效。方法将100例急性髓细胞白血病患者按随机数字表法分为治疗组和对照组,各50例。对照组采用西医常规化疗手段治疗。治疗组在对照组基础上,联用验方参芪杀白汤中药治疗。结果治疗组总有效率为92.00%,高于对照组的74.00%(P<0.05)。两组初治与复发患者总有效率比较,结果示初治患者,治疗组总有效率为96.97%,高于对照组的80.65%(P<0.05)。复发患者、治疗组总有效率为76.47%,高于对照组的52.63%(P<0.05)。治疗组与对照组比较,两组初治患者总有效率均高于复发患者(P<0.05)。两组骨髓抑制期各项指标比较,结果示治疗组在改善粒细胞缺乏时间、输注悬浮红细胞、输注血小板方面优于对照组(P<0.05)。两组安全性指标比较,结果为治疗组50例患者,出现胃肠道反应13例(26.00%),肝功能损伤1例(2.00%),肾功能损伤5例(10.00%);对照组胃肠道反应19例(38.00%),肝功能损伤14例(28.00%),肾功能损伤6例(12.00%)。治疗组不良反应少于对照组(P<0.05)。结论验方参芪杀白汤联合化疗治疗急性髓细胞白血病可明显提高患者完全缓解率和总有效率。治疗组中复治患者完全缓解率虽优于对照组复治患者,但总体疗效仍差于初治患者,这也说明应进一步优化组方,或调整中西医结合治疗切入点以期进一步提高疗效。

Objective： To observe the clinical effects of proved recipe Shenqi Shabai Decoction combined with chemotherapy on acute myelocytic leukemia. Methods： 100 patients with acute myeloid leukemia were randomly divided into two groups： the treatment group and the control group,50 cases in each. The control group was treated with conventional western medicine treatment. The treatment group,on the basis of the control group,was added proved recipe Shenqi Shabai Decoction. Results： The total effective rate of the treatment group was92.00%,higher than that of the control group 74.00%（P〈 0.05）. The comparison of total effective rate between primary and recurrent patients in the two groups showed that in the initial treatment patient group,the total effective rate of the treatment group was 96.97%,higher than that of the control group 80.65%（P〈 0.05） and that in the recurrence group,the total effective rate of the treatment group was 76.47%,higher than that of the control group 52.63%（P〈 0.05）. The comparison of the indexes of bone marrow depression in two groups showed that the treatment group was superior to the control group in improving the time of granulocyte deficiency,the suspension of red blood cells and platelet transfusion（P〈 0.05） and that adverse reactions in the treatment group were less than those in the control group（P〈 0.05）. Conclusion： Proved recipe Shenqi Shabai Decoction combined with chemotherapy on acute myelocytic leukemia can obviously improve the complete remission rate and total effective rate. Although the complete remission rate of re-treated patients in the treatment group was better than that of the control group,the overall effect was still worse than the initial treatment,which indicates that we should further optimize the prescription,rr adjust the breakthrough point of the combination of traditional Chinese and Western medicine to further improve the efficacy.