肠乐胶囊治疗腹泻型肠易激综合征的药效学研究

Pharmacodynamics of Changle Capsules in the treatment of diarrhea-predominant irritable bowel syndrome

目的研究肠乐胶囊(高良姜、白术、白芍等)治疗腹泻型肠易激综合征(IBS)的药效学。方法以番泻叶腹泻模型、蓖麻油腹泻模型和新斯的明肠运动亢进模型观察肠乐胶囊的止泻作用;以新生大鼠乙酸刺激法建立内脏高敏性IBS大鼠模型,观察肠乐胶囊对大鼠肠道敏感性、肠运动以及肠粘膜组织形态学的影响。结果肠乐胶囊可明显抑制番泻叶所致的腹泻和新斯的明所致的小肠运动亢进(P<0.05,P<0.01),但对蓖麻油引起的腹泻无效;肠乐胶囊可显著降低内脏高敏性IBS大鼠的敏感性,以及小肠碳末推进率和急性避水应激排便粒数(P<0.05,P<0.01)。结论肠乐胶囊可有效对抗腹泻,降低肠道敏感性,对腹泻型IBS有较好的治疗作用。

AIM To study the pharmacological effect of Changle Capsules（ Alpiniae officinarum Rhizoma,Atractylodis macrocephalae Rhizoma,Paeoniae Radix alba,etc.） in treating diarrhea-predominant irritable bowel syndrome（ IBS）. METHODS The senna diarrhea model,castor oil diarrhea model and neostigmine-inducedbowel movement hyperfunction were adopted to observe the anti-diarrhea effect of Changle Capsules. The injection of acetic acid into neonatal rats created the visceral hypersensitivity model of IBS for observating Changle Capsules on the intestinal tract sensitivity,intestinal motility and intestinal mucosa morphology. RESULTS Changle Capsules effectively inhibited senna-induced diarrhea and neostigmine-induced bowel movement（ P〈0. 05, P〈0. 01）,but had no obvious effect on castor oil-induced diarrhea. This drug obviously inhibited intestinal tract sensitivity,carbon propelling rate and feces number in acute water avoidance stress in visceral hypersensitivity rat model for IBS（ P〈0. 05,P〈0. 01）. CONCLUSION Changle Capsules can effectively treat diarrhea and reduces intestinal sensitivity,which has good curative effect against diarrhea-predominant IBS.