抗VEGF/VEGFR靶向药物的治疗进展

The therapy progress of target drugs of anti-VEGF / VEGFR

肿瘤微环境在肿瘤的起源、生长和转移中发挥重要作用,而新生血管是肿瘤生长和转移所必需的,血管的生成需要大量调节血管生成的细胞因子参加,而血管内皮生长因子(vascular endothelial growth factor,VEGF)是最重要的促血管生成因子。阻断VEGF通路中某一环节,均有可能有效地抑制肿瘤血管生成,使肿瘤血管退化脱落,产生抗肿瘤作用。根据VEGF的调控特点,已出现多种以VEGF/VEGFR为靶点的抗肿瘤血管生成药物。本文就抗VEGF的靶向药物治疗及特点作一概述。

Tumor microenvironment plays an important role in tumor,including the origin,growth and metastasis.And angiogenesis is essential for tumor growth and metastasis,lots of cytokines take part in angiogenesis,and vascular endothelial growth factor（ VEGF） is the most important one of them. Blocking the VEGF pathway can inhibit tumor angiogenesis,and improve the degradation of tumor vessel,also produce broad-spectrum anti-tumor effect. According to the characteristics of VEGF regulation,the tumor angiogenesis drugs with VEGF / VEGFR as the target have appeared.The characteristics of target drugs of anti VEGF were summarized in this paper.