全身热疗联合化疗治疗116例恶性肿瘤患者的临床观察

Clinical Research of Whole Body Hyperthermia Combined with Chemotherapy in the Treatment of Malignant Tumor for 116 Cases

目的观察全身热疗联合化疗治疗恶性肿瘤的疗效及不良反应。方法 58例恶性肿瘤患者（A组）接受全身热疗联合化疗,全身热疗采用SRI全身热疗系统,温度40℃±0.5℃,持续90~120 min,1次/3周。另外58例（B组）只接受单纯化疗。结果 A组12个月及96个月生存率（82.76%和67.25%）均高于B组（77.60%和50%）,且两组比较差异有显著性意义（P〈0.05）,A组中位PFS（27个月）较B组（20个月）长7个月,两组比较差异有显著性意义（P〈0.05）,两组不良反应发生率差异无统计学意义（P〉0.05）。不良反应主要包括胃肠道反应及骨髓抑制。结论全身热疗联合化疗方案组治疗对恶性肿瘤疗效好,不良反应轻,是治疗恶性肿瘤较好的方案。

Objective To observe the efficacy and toxicity of whole body hyperthermia combined with chemotherapy in the treatment of malignant tumor. Methods 58 patients with malignant tumor were treated by conventional chemotherapy combined with whole body hyperthermia（group A）. We used SRI WBH system,and the temperature was（40±0.5） ℃,lasting for 90-120 minutes,once per 3 weeks. Another 58 patients received conventional chemotherapy only（group B）. Results The overall survival（OS） rates of 12-month and 96-month in group A（82.76% and 67.25%） were higher than that in group B（77.60% and 50%）. There was significant difference in OS between the two groups（P 〈0.05）. The median progression-free survival（PFS） in group A（27-month） was longer seven months than group B（20-month）. There was significant difference between the two groups（P〈0.05）. The main toxicities were gastrointestinal tract, and myeloma suppression. Conclusion Whole body hyperthermia combined with chemotherapy has a good anti-tumor activity and tolerable toxicity on malignant tumor patients.