摘要
Poor differentiation is an important hallnnark of cancer cells,and differentiation therapy holds great promise for cancer treatment.The restoration of IkB kinase a(IKKa)leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity.The findings by Yan et al.validate the polycomb protein enhancer of zeste homologue2(EZH2)as a target for intervention.
Poor differentiation is an important hallmark of cancer cells,and differentiation therapy holds great promise for cancer treatment.The restoration of IkB kinase a(IKKa) leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity.The findings by Yan et al.validate the polycomb protein enhancer of zeste homologue2(EZH2) as a target for intervention.
基金
the National Basic Research Program of China(973 Program,No.2012CB967000 and 2011CB504300 to QL)
Program for Chang Jiang Scholars and Innovative Research Team in University(IRTI 3049 to QL)
National Natural Science Foundation of China(No.30888003 to QL and No.81201547 to MY)
Guangdong Medical Science Fund(A2011198 to MY)
