摘要
Viral infections contribute to approximately 12%of cancers worldwide,with the vast majority occurring in developing countries and areas.Two DNA viruses,Epstein-Barr virus(EBV) and human papillomavirus(HPV),are associated with38%of all virus-associated cancers.The probability of one patient infected with these two distinct types of viruses is increasing.Here,we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.
Viral infections contribute to approximately 12%of cancers worldwide,with the vast majority occurring in developing countries and areas.Two DNA viruses,Epstein-Barr virus(EBV) and human papillomavirus(HPV),are associated with38%of all virus-associated cancers.The probability of one patient infected with these two distinct types of viruses is increasing.Here,we summarize the co-infection of EBV and HPV in human malignancies and address the possible mechanisms for the co-infection of EBV and HPV during tumorigenesis.
基金
supported by the National Basic Research Program of China[2011CB504300(Y.T.
Y.C.),2015CB553903(Y.T.)]
the National High Technology Research and Development Program of China(863 Program)[2012AA02A501(Y.C.)]
the National Natural Science Foundation of China[81,171,881 and81372427(Y.T.),81271763(S.L.),81,302,354(Y.S.)]
the Hunan Natural Science Foundation of China[12JJ1013(Y.T.)]
