慢性肝炎患者甲胎蛋白检测的临床意义与结果分析

Clinical significance of AFP in patients with chronic hepatitis

目的:检测慢性肝炎患者血清甲胎蛋白的变化,便于判断预后效果及早期发现癌变。方法:随机抽取我院肝病科住院治疗的慢性肝炎患者165例作为研究对象,按诊断标准分型,采用放射免疫法检测血清AFP水平。结果:慢性重度肝炎、肝硬化及肝细胞癌患者血清中的AFP水平检测结果分别是(243.427±16.318)、(310.090±35.885)、(393.957±15.336),慢性轻度、中度及重型肝炎患者血清中的AFP水平检测结果分别是(4.929±1.968)、(21.637±18.246)、(5.395±1.870),慢性重度肝炎、肝硬化及肝细胞癌患者血清中的AFP明显高于慢性轻度、中度和重型肝炎患者,P<0.005。结论:AFP作为肝细胞癌最具特异性的标志物,可在肝炎患病群体中用于肝癌的普查、诊断、判断治疗效果和预测病情。

Objective： To detect the changes of serum alpha-fetoprotein in patients with chronic hepatitis for prognosis and facilitate early detection of cancer. Methods： 165 cases was selected to adopted serum AFP levels by radioimmunoassay. Results： In patients with severe chronic hepatitis, cirrhosis and hepatocellular carcinoma, serum AFP level test results are respectively（243.427 ± 16.318）,（310.090 ± 35.885）,（393.957 ± 15.336）; in chronic mild, moderate and severe hepatitis patients, serum AFP level were（4.929 ± 1.968）,（21.637 ± 18.246）,（5.395 ± 1.870）; in patients with severe chronic hepatitis, cirrhosis and hepatocellular carcinoma, serum AFP were significantly higher, P〈0.005. Conclusion： AFP as the most specific marker of hepatocellular carcinoma, liver cancer, can be used in the census population prevalence of hepatitis, diagnosis, treatment.