无症状肝功酶学指标异常的系统观察及在健康状况评估中的价值

Observation on value of asymptomatic liver enzyme abnormalities in health status assessment

目的:观察无症状肝酶学指标异常与轻度器质性病变的关系,探讨无症状肝功酶学指标异常在健康状况评估中的应用价值。方法:选择2012年11月-2014年11月期间于我院体检的240例体检者的临床资料,根据肝功能酶学指标(ALT、AST、GGT)的不同将240例分为健康组、轻度异常组(一个指标异常)、中度异常组(两个指标异常)、重度异常组(三个指标均异常),每组各60例,对4组患者进行超声、X线、CT等影像学检查,统计各组患者影像学检查疾患检出率,并行统计学对比。结果:健康组器质性病变的疾患检出2例,检出率为3.33%,轻度异常组检出率为11.7%(7例),中度异常组检出率为21.7%(13例),重度异常组检出率为28.3%(17例),组间数据比较差异明显,存在统计学意义(P<0.05)。结论:肝功能酶学指标对于器质性疾患敏感性高,通常在疾患未导致机体出现明显症状之前就能发生表达水平的异常,通过对肝功能酶学指标的检测能较早发现轻度器质性病变,利于早诊断、早治疗,有积极的临床意义。

Objective： To investigate the relationship between liver enzyme abnormalities in asymptomatic and mild organic disease, to explore applications of asymptomatic liver enzyme abnormalities in health status assessment. Methods： The subjects included 240 cases, based on indicators of liver function enzyme（ALT, AST, GGT） were divided into different groups： healthy group, mildly abnormal group（an indicator of an exception）, moderately abnormal group（two abnormalities）, severe abnormal group（three indicators are an exception）, 60 cases in each group. Results： Healthy group organic lesions detected in two cases of disease, rate of 3.33%; mildly abnormal detection rate was 11.7%（7 cases）; moderately abnormal group went to 21.7%（13 cases）, and severe abnormal group was 28.3%（17 cases）; those rates are significantly different（P〈0.05）. Conclusion： The liver function enzyme index was higher sensitivity for organic disorder; abnormalexpression levels can occur before obvious symptoms of liver function, by detecting enzymatic indicators earlier discovery organic disease can slightly predicted, in favor of early diagnosis, early treatment, with positive clinical significance.