血清C反应蛋白水平对难治性类风湿关节炎的诊断价值评述

Diagnostic value of serum C-reactive protein levels to refractory rheumatoid arthritis

目的:研究血清C反应蛋白水平对难治性类风湿关节炎的诊断价值。方法:将我院2012年2月-2013年1月收治的150例难治性类风湿关节炎(RRA)作为本次研究的对象,经患者同意,现对其进行随机分组,即实验组与对照组,两组关节炎患者各75例。实验组患者分别采用甲氨蝶呤(MTX)和柳氮磺砒啶栓(SASP)进行治疗,对照组患者采用常规药物进行治疗,两组患者均治疗10周,并从第7周开始,对两组关节炎患者的C反应蛋白水平进行检测。结果:两组关节炎患者经过治疗后发现,实验组患者的C反应蛋白水平均高于对照组患者,两组之间存在明显差异,P<0.05,差异具有统计学意义。结论:甲氨蝶呤和柳氮磺砒啶栓能够有效治疗难治性类风湿关节炎,并且C反应蛋白能将其治疗效果展现出来,为诊断提供相应的依据,具有一定的积极意义。

Objective To study diagnostic value of serum C-reactive protein level to refractory rheumatoid arthritis. Methods：150 patients with refractory rheumatoid arthritis were divided into the experimental group and control group, 75 in each group. Theexperimental group was given methotrexate and sulfasalazine suppository arsenic pyridine treatment; the control group was treated withconventional drugs. Results： After 10 weeks, C-reactive protein levels were higher in the control group; there are significant differencesbetween two groups, P〈0.05. Conclusion： Soft methotrexate and sulfasalazine pyridine bolt can effectively improve refractory rheumatoidarthritis. C-reactive protein and its therapeutic effects can show up, with some positive significance.