芪苈强心胶囊对冠心病患者心脏舒张功能的影响

Effect of qiliqiangxin capsule on left ventricular diastolic function in patients with coronary heart disease

目的:探讨芪苈强心胶囊对冠心病患者心脏舒张功能的影响。方法:选择"IL-33和e NOS基因标签SNPs与冠心病发生的关联研究"中经冠脉造影明确诊断为冠心病,左心功能正常而存在左室舒张功能异常、未行冠脉介入治疗的患者89例,其中43例患者在冠心病二级预防治疗基础上加用芪苈强心胶囊治疗作为治疗组,46例患者仅给予冠心病二级预防作为对照组,观察12周,采用多普勒超声心动图检测冠心病患者治疗前后左室收缩功能指标射血分数(LVEF),左室舒张功能指标E波峰值速度(E),A波峰值速度(A),E峰与A峰速度比值(E/A),对2组患者治疗前后上述指标变化进行统计学分析。结果:2组患者治疗后左室收缩功能指标及舒张功能指标较治疗前相比较均有改善,差异有统计学意义(P<0.05);治疗组左室收缩功能指标及舒张功能指标较对照组改善较好,差异有统计学意义(P<0.05)。结论:芪苈强心胶囊对冠心病患者左室舒张功能有改善作用。

Objective： To evaluate the effect of qiliqiangxin capsule on left ventricular diastolic function in patients with coronary heart disease. Methods： 89 cases of patients with coronary heart disease accompanied by ventricular diastolic dysfunction were randomly divided into two groups,a treatment group（ n = 43） and a control group（ n = 46）. The control group was just given grade 2 prevention treatment,and the treatment group,on the basis of the control group treatment,was added with qiliqiangxin capsule 1. 2g,3 times per day for 12 weeks. Results： After treatment,the left ventricular diastolic function indicator（ E / A ratio） and left ventricular systolic function indicator（ LVEF） of the two groups significantly improved（ P〈0. 05）. The left ventricular diastolic function indicator（ E / A ratio） and left ventricular systolic function indicator（ LVEF） of the treatment group improved better compared with the control group（ P 0. 05）. Conclusion： Grade 2 prevention and treatment of coronary heart disease combined with qiliqiangxin capsule can improve left ventricular diastolic function and left ventricular systolic function in patients with coronary heart disease.