摘要
目的:探讨无抽搐电休克治疗(modified electroconvulsive therapy,MECT)术后不良反应及其相关因素。方法 :对2014年到2015年期间,在上海市嘉定区精神卫生中心住院期间接受MECT治疗的964例精神障碍患者进行MECT术后不良事件的记录和比较。结果 :共报告不良事件119例(12.34%);女性报告不良事件的发生率显著高于男性(χ~2=13.964,P=0.000)。不同精神疾病的不良事件报告率存在显著差异(χ~2=9.736,P=0.004),其中情感性障碍的不良事件报告率最高。丙泊酚麻醉后导致近记忆减退的发生率显著高于依托咪酯(χ~2=8.111,P=0.005);而依托咪酯麻醉后导致急性谵妄的发生率显著高于丙泊酚(χ~2=9.201,P=0.003)。结论 :MECT在治疗上总体安全,但也应注意其不良反应并及时处理,特别是发生意识不清(急性谵妄)时,应密切观察。
Objective: To explore the adverse event and related factors of modified electroconvulsive therapy(MECT) on patients with mental disorder. Methods: The data of post-operative adverse events in the patients who received MECT during hospitalization from 2014 to 2015 in Jiading Mental Health Center,Shanghai were retrospectively analyzed. Results: The adverse events were seen in 119 cases of patients(12.34%) and the incidence of adverse events was significant higher in female than male(χ~2=13.964,P=0.000). There existed some obvious differences in the reported incidence of adverse events in different kinds of mental disorders(χ~2=9.736,P=0.004),in which the highest occurred in the patients with affective disorder. The incidence of recency memory decline caused by propofol anesthesia was obviously higher than that by etomidate(χ~2=8.111,P=0.005)while the incidence of acute delirium caused by etomidate was higher than that by propofol(χ~2=9.201,P=0.003). Conclusion: MECT is a safe and effective treatment method in clinic,but the adverse reaction should be carefully monitored and intervened in time,especially when the acute delirium occurs.
出处
《上海医药》
CAS
2016年第5期53-55,59,共4页
Shanghai Medical & Pharmaceutical Journal
基金
上海市嘉定区卫计委课题(2015-ky-11)