颅内动脉狭窄支架成形术后支架内急性血栓形成相关研究

Acute in-stent thrombosis after stent angioplasty for intracranial artery stenosis: a clinical study

目的探讨颅内动脉狭窄支架成形术后支架内急性血栓形成的可能原因及干预措施。方法回顾性分析102例接受Wingspan支架成形术治疗的症状性动脉粥样硬化性颅内动脉狭窄患者中5例(4.9%)发生支架内急性血栓形成患者的临床资料。结果支架植入术后5 min^6 h,5例患者脑血管造影证实支架内急性血栓形成,给予动脉内溶栓治疗后均获再通,无溶栓相关致残致死情况发生。结论颅内动脉狭窄支架成形术后支架内急性血栓形成原因多样,积极的干预措施可减少不良后果发生。

Objective To investigate the possible causes and the intervention measures of acute instent thrombosis after stent angioplasty for intracranial artery stenosis. Methods A total of 102 patients with symptomatic atherosclerotic intracranial artery stenosis, who received Winspan stent angioplasty, were collected. Among the 102 patients, acute in-stent thrombosis occurred in 5, and their clinical data were retrospectively analyzed. Results In the 5 patients, the acute in-stent thrombosis occurred within the period from 5 minutes to 6 hours after stent implantation. Vascular re-canalization was successfully achieved in all 5 patients after intra-arterial thrombolysis therapy, and no thrombolysis-related complication occurred. Conclusion The causes of acute in-stent thrombosis after stent angioplasty for intracranial artery stenosis are various, and active intervention measures can reduce the incidence of adverse outcomes.