亚急性脑卒中患者静息态功能磁共振成像

Resting-state functional magnetic resonance imaging in sub-acute stroke

目的探讨应用静息态功能磁共振成像(rs-fMRI)对缺血性脑卒中患者病灶区进行检测的可行性。方法收集14例亚急性缺血性脑卒中患者,分析其rs-fMRI数据,包括病灶区和正常对照区平均信号的低频振幅、两区域间相位延迟前后的功能连接和相位延迟3项主要指标。结果 1低频振幅分析:4例患者病灶区低频振幅增强,10例病灶区低频振幅减弱;14例患者病灶区和正常对照区低频振幅的差异无统计学意义(t=-1.6290,P=0.1273)。2功能连接分析:42.86%(6/14)的患者病灶区与正常区的功能信号存在相位差异。3相位延迟分析:对于正常区,6例患者与全脑信号无相位差异,4例相位超前,4例相位落后;对于病灶区,8例相位超前,6例相位落后。14例患者两侧区域相对全脑的时间延迟值差异无统计学意义(t=0.6288,P=0.5404)。结论缺血性脑卒中会引起rs-fMRI相关特异性指标的改变,但各指标个体差异明显,一致性不高。

Objective To explore the feasibility of resting-state functional magnetic resonance imaging（rs-fMRI）in the detection of ischemic stroke region.Methods Totally 14sub-acute ischemic stroke patients were collected,the rs-fMRI data were analyzed in three key indicators,including the amplitude of low frequency fluctuation（ALFF）of normal and abnormal regions,bilateral functional connectivity with/without phase delay,and the phase-lagged correlation with wholebrain global signal.Results ①ALFF analysis：Four patients showed increased ALFFs in stroke area,10 had decreased ALFFs.And the differences of ALFF values of all 14 patients in normal and abnormal areas had no statistical significance（t=-1.6290,P=0.1273）.②Functional connectivity analysis：About 42.86%（6/14）patients had phase differences between lesion and health areas.③Phase-lagged correlation analysis：Comparing with global signal,in health areas,6patients showed no phase difference,4showed advanced phases and the remaining 4showed delayed phases,while in lesion areas,8patients showed advanced phases,6showed delayed phases.And the differences between the phase delays of bilateral regions related to the whole brain global signal of 14 patients had no statistical significance（t=0.6288,P=0.5404）.Conclusion The rs-fMRI measurements are altered caused by ischemic stroke.While great variations across individuals are also observed which had no strong consistency.