β_1肾上腺素受体基因多态性与高血压易感性及治疗的研究进展

Research progress of association between β_1 adrenergic receptor gene polymorphisms,hypertension susceptibility and treatment

β_1肾上腺素受体(β_1adrenergic receptor,β_1-AR)属于G蛋白偶联受体超家族,研究表明β_1-AR基因多态性与高血压发生、发展及临床药物疗效密切相关。β_1-AR基因多态性通过影响G蛋白-腺苷酸环化酶-环磷酸腺苷-蛋白激酶A(GsAC-c AMP-PKA)信号通路参与血压调控。同时,β_1-AR基因多态性是影响β-AR阻滞剂个体疗效差异的重要遗传因素。β_1-AR基因多态性的研究不仅揭示了调控高血压信号通路的新机制,而且为高血压临床个体化用药方案的制定提供理论依据和参考。

β_1 adrenergic receptor is one of G protein-coupled receptor superfamily. β_1-AR gene polymorphisms are closely related to the occurrence,development and treatment of hypertension. Numerous studies have shown that β_1-AR activates the GSAC-c AMP-PKA signal pathway to regulate the blood pressure. Furthermore,β_1-AR gene polymorphisms have been shown to cause differences in blood pressure response to β-AR blockers. Researches on β_1-AR gene polymorphisms not only reveal new insight into the hypertension regulation signals, but also provide the theoretical basis and guidance for individualized clinical treatment of hypertension.