阿尔茨海默病患者血清中抗氧化物与认知损伤的相关性分析

The analysis on correlation between serum antioxidant and cognitive impairment in patients with Alzheimer's disease

目的分析阿尔茨海默病(AD)患者血清中抗氧化物与认知损伤的相关性。方法分析2014年1—6月在承德医学院附属医院神经内科接受治疗的41例被诊断为阿尔茨海默病患者的临床资料,设为观察组,另选取健康体检的老年人44例作为健康对照组。比较2组MMSE总评分、血脂、氧化指标及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、尿液中8-异前列腺素F2α(8-iso-PGF2α)含量。结果观察组患者简易精神状态量表(MMSE)总评分明显低于健康对照组(t=8.813,P<0.01),命名能力、语言能力、延迟回忆、定向能力、视空间和执行力、注意力和计算能力评分均低于健康对照组(P<0.05);2组患者血清TG、TC、HDL-C和LDL-C水平比较,差异无统计学意义(P>0.05);观察组患者血清中SOD、GSH-Px水平低于健康对照组(t=3.973、5.966,P<0.05),MDA水平及尿8-iso-PGF2α水平高于健康对照组(t=12.25、46.18,P<0.01);血清SOD与MMSE评分呈正相关(r=0.527,P<0.01),GSH-Px与MMSE评分呈正相关(r=0.471,P=0.002),同时尿液中8-异前列腺素F2α与MMSE评分呈负相关(r=-0.456,P=0.003)。结论 SOD、GSH-Px活力下降,MDA、8-异前列腺素F2α水平升高可能共同参与了AD患者认知损害的发病过程,可用于临床诊断和治疗。

Objective To investigate the correlation between serum antioxidant and cognitive impairment in patients with Alzheimer＇ s disease（AD）.Methods Analyzing clinical data of 41 cases Alzheimers patients for treatment in the Chengde Medical College Affiliated Hospital from Januan 2014 to June 2014,they were selected as observation group,and 44 cases elderly health people for check-up were selected as control group.MMSE total scores,blood lipid,oxidation index and superoxide dismutase（SOD）,glutathione peroxidase（GSH-Px） and the amount of 8-iso-prostuglandin（8-iso-PGK2α） in urine were compared between the two groups.Results MMSE total scores in observation group patients was obviously lower than the control group,the difference is statistically significant（t =8.813.P〈0.01）.The scores of naming ability.language ability,delayed recall,directional ability,visual space and execution,attention and calculation ability in control group were higher than the observation group,difference have statistically significant（P〈0.05）;Compared to serum TG,TC,HDL-C and LDL-C level in two groups patients,difference have no statistically significant（P〉0.05）.The MDA amd urine 8-isoPGF2α level in observation group were significantly higher than the control group,the difference was statistically significant（t = 12.25,t =46.18,P〈0.01）;serum SOD（t =3.973,P〈0.01）,GSH-Px（t =5.966,P〈0.01） levels in the observation group of patients were significantly lower than the control group,the difference have statistically significant（P〈0.05）.By Pearson correlation analysis,serum SOD in observation group appears positive correlation with MMSE score（r =0.527.P〈0.01）,GSH-Px appears positive correlation with MMSE score（r =0.471,P =0.002）.at the same lime,the8-iso-PGF2α in urine showed significant negative correlation with MMSE score（r =- 0.456,P = 0.003）.Conclusion The decrease of SOD,GSH-Px and rising of MDA,8-iso-PGF2α leyel play an important role in the onset of cognitive impairment of AD patients,they can be used for clinical diagnosis and treatment.