组织蛋白酶在心脏重塑中作用的研究进展

Role of cathepsins in cardiac remodeling

许多心血管疾病都伴随着心脏重塑的发生，导致心脏结构改变和功能异常，最终发展为心力衰竭，严重威胁人类的生命健康。组织蛋白酶是一种溶酶体蛋白酶，包括K、S、L等十几种亚型。许多研究提示，组织蛋白酶与心脏重塑的发生发展密切相关，本文对组织蛋白酶在心脏重塑中作用的研究现状进行综述。

Many cardiovascular diseases are associated with cardiac remodeling, resulting in abnormal cardiac structure and function, and finally for heart failure. This is a serious threat to human life and health. Cathepsin is a kind of lysosomal proteases, including dozens of subtypes such as K, S, L. Many studies suggest that eathepsiu is closely related to the occurrence and development of cardiac remodeling. This study reviewed the research status of ca- thepsin roling in cardiac remodeling.