巨噬细胞极化与动脉粥样硬化

Macrophage Polarization and Atherosclerosis

巨噬细胞可极化成两种亚型,促炎的M1型和抗炎的M2型,通过调控炎症反应可影响动脉粥样硬化发展进程。研究表明,巨噬细胞极化在动脉粥样硬化病理生理中发挥了重要作用,但目前调控巨噬细胞极化决定动脉粥样硬化炎症反应转归的机制尚不十分清楚。本文重点就动脉粥样硬化发展过程中影响巨噬细胞极化的因素做一阐述,为调节炎症反应防治动脉粥样硬化提供一个新研究方向。

Macrophage can polarize two subtypes,pro-inflammatory M1 and anti-inflammatory M2,which affect the development process of atherosclerosis through regulatory inflammation. Studies suggest,although macrophage polarization plays an important role in pathophysiology of atherosclerosis,it is not clear that mechanism of regulatory macrophage polarization determines the outcome of inflammation in atherosclerosis. In this review,we can provide a new direction of preventing atherosclerosis and controlling inflammation through influence factors of macrophage polarization in atherosclerotic inflammation.