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Synthetic cell pathobiology to study neurodegeneration： defining new therapeutic targets in astroglia 被引量：1

Synthetic cell pathobiology to study neurodegeneration: defining new therapeutic targets in astroglia
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摘要 Synthetic biology is the design and construction of new biological parts,devices,and systems,and the re-design of existing,natural biological systems for useful purposes.This new interdisciplinary effort has gained interest from the industry sector,and synthetic biology has been used to produce fragrances,such as vanillin in yeast,in cells that do not normally exist in nature. Synthetic biology is the design and construction of new biological parts,devices,and systems,and the re-design of existing,natural biological systems for useful purposes.This new interdisciplinary effort has gained interest from the industry sector,and synthetic biology has been used to produce fragrances,such as vanillin in yeast,in cells that do not normally exist in nature.
作者 Matjaz Stenovec: Robert Zorec
机构地区 Celica Biomedical
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第2期234-235,共2页 中国神经再生研究（英文版）
基金 supported by the Slovenian Research Agency grants P3310,J3 3632,J3 4051,J3-4146,J3 6790,J3 7605
分类号 Q421 [生物学—神经生物学] Q255 [生物学—细胞生物学]
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参考文献11

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  • 2Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V (2015) Direct conversion of fibroblasts into functional astrocytes by defined transcription factors. Stem Cell Reports 4:25-36.
  • 3Carlquist M, Gibson B, Karagul Yuceer Y, Paraskevopoulou A, Sandell M, Angelov AI, Gotcheva V, Angelov AD, Etschmann M, de BiIlerbeck GM, Liden G (2015) Process engineering for bioflavour production with metabolically active yeasts - a mini-review. Yeast 32:123 - 143.
  • 4Olabarria M, Noristani HN, Verkhratsky A, Rodriguez JJ (2010) Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia 58:831-838.
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  • 6Stenovec M, Trkov S, Lasic E, Terzieva S, Kreft M, Rodriguez Arellano JJ, Parpura V, Verkhratsky A, Zorec R (2016) Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment. Glia 64:317-329.
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  • 9Vardjan N, Verkhratsky A, Zorec R (2015) Pathologic potential of astrocytic vesicle traffic: new targets to treat neurologic diseases? Cell Transplant 24:599-612.
  • 10Verkhratsky A, Parpura V (2016) Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders. Neurobiol Dis 85:254-261.

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Neural Regeneration Research
2016年 第2期

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